Lisinopril
- Generic Name
- Lisinopril
- Brand Names
- Prinivil, Qbrelis, Zestoretic, Zestril
- Drug Type
- Small Molecule
- Chemical Formula
- C21H31N3O5
- CAS Number
- 76547-98-3
- Unique Ingredient Identifier
- 7Q3P4BS2FD
- Background
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction. Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.
Lisinopril was granted FDA approval on 29 December 1987.
- Indication
Lisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure. A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.
- Associated Conditions
- Acute Myocardial Infarction (AMI), Cardiovascular Events, Congestive Heart Failure (CHF), Diabetic Nephropathy, Hypertension, Migraine
The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors
- Conditions
- Hypertension, Resistant to Conventional Therapy
- Interventions
- First Posted Date
- 2015-12-07
- Last Posted Date
- 2017-05-25
- Lead Sponsor
- Memorial Health University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT02623036
- Locations
- 🇺🇸
Memorial Family Medicine Center, Savannah, Georgia, United States
Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension
- Conditions
- Essential Hypertension
- Interventions
- First Posted Date
- 2015-11-13
- Last Posted Date
- 2022-11-23
- Lead Sponsor
- Idorsia Pharmaceuticals Ltd.
- Target Recruit Count
- 1659
- Registration Number
- NCT02603809
- Locations
- 🇺🇸
LCC Medical Research Institute, Miami, Florida, United States
🇺🇸Allied Biomedical Research Institute, INC, Miami, Florida, United States
🇺🇸Midwest Institute for Clinical Research, Indianapolis, Indiana, United States
Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
- Conditions
- Perioperative Hypertension
- Interventions
- First Posted Date
- 2015-05-12
- Last Posted Date
- 2017-02-08
- Lead Sponsor
- Milton S. Hershey Medical Center
- Target Recruit Count
- 85
- Registration Number
- NCT02441842
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
- Conditions
- Essential Hypertension
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2018-11-15
- Target Recruit Count
- 42
- Registration Number
- NCT02412761
- Locations
- 🇺🇸
University of Texas at Houston Medical School; Pediatric Nephrology and Hypertension Clinics, Houston, Texas, United States
Modulation of Heme Oxygenase 1 by Nizatidine and Lisinopril in Healthy Subjects
- First Posted Date
- 2014-09-05
- Last Posted Date
- 2015-04-30
- Lead Sponsor
- Adil Bharucha
- Target Recruit Count
- 24
- Registration Number
- NCT02232308
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
🇺🇸Mayo Clinic, Rochester, Minnesota, United States
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects
- Conditions
- HealthyDiabetes
- Interventions
- First Posted Date
- 2014-02-25
- Last Posted Date
- 2020-02-17
- Lead Sponsor
- Novo Nordisk A/S
- Target Recruit Count
- 52
- Registration Number
- NCT02070510
- Locations
- 🇩🇪
Novo Nordisk Investigational Site, Berlin, Germany
Non-invasive Haemodynamic Assessment in Hypertension
- Conditions
- Arterial Hypertension
- Interventions
- Drug: Indapamide/hydrochlorothiazide
- First Posted Date
- 2013-11-27
- Last Posted Date
- 2018-03-13
- Lead Sponsor
- Military Institute od Medicine National Research Institute
- Target Recruit Count
- 144
- Registration Number
- NCT01996085
- Locations
- 🇵🇱
Military Institute of Medicine, Warsaw, Mazovia, Poland
CAndesartan vs LIsinopril Effects on the BRain
- Conditions
- Mild Cognitive ImpairmentHypertension
- Interventions
- First Posted Date
- 2013-11-14
- Last Posted Date
- 2021-02-21
- Lead Sponsor
- Emory University
- Target Recruit Count
- 176
- Registration Number
- NCT01984164
- Locations
- 🇺🇸
Emory Univeristy, Atlanta, Georgia, United States
Cardiomyopathy in DMD: Lisinopril vs. Losartan
- Conditions
- Duchenne Muscular Dystrophy (DMD)Cardiomyopathy
- Interventions
- First Posted Date
- 2013-11-13
- Last Posted Date
- 2017-03-21
- Lead Sponsor
- Nationwide Children's Hospital
- Target Recruit Count
- 23
- Registration Number
- NCT01982695
- Locations
- 🇺🇸
University of California Davis, Davis, California, United States
🇺🇸Boston Children's Hospital, Boston, Massachusetts, United States
🇺🇸St. Louis Children's Hospital, St. Louise, Missouri, United States
Bioequivalence Study of Two Formulations of 10 mg Lisinopril Tablet Under Fasting Condition
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2013-09-05
- Last Posted Date
- 2013-09-05
- Lead Sponsor
- Dexa Medica Group
- Target Recruit Count
- 34
- Registration Number
- NCT01936012
- Locations
- 🇮🇩
PT Equilab International, Jakarta, Indonesia
Drug Development Updates
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