Tioconazole
- Generic Name
- Tioconazole
- Brand Names
- Monistat Simple Therapy, Vagistat
- Drug Type
- Small Molecule
- Chemical Formula
- C16H13Cl3N2OS
- CAS Number
- 65899-73-2
- Unique Ingredient Identifier
- S57Y5X1117
Overview
Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
Background
Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
Indication
For the local treatment of vulvovaginal candidiasis (moniliasis).
Associated Conditions
- Fungal skin infection
- Infection, Mixed
- Onychomycosis
- Vaginal Candidiasis
- Vulvovaginal Candidiasis
- Bacterial skin infections
- Cutaneous dermatophyte infection
- Superficial Fungal skin infection
Clinical Trials
FDA Approved Products
Singapore Approved Products
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