Tioconazole
- Generic Name
- Tioconazole
- Brand Names
- Monistat Simple Therapy, Vagistat
- Drug Type
- Small Molecule
- Chemical Formula
- C16H13Cl3N2OS
- CAS Number
- 65899-73-2
- Unique Ingredient Identifier
- S57Y5X1117
- Background
Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
- Indication
For the local treatment of vulvovaginal candidiasis (moniliasis).
- Associated Conditions
- Fungal skin infection, Infection, Mixed, Onychomycosis, Vaginal Candidiasis, Vulvovaginal Candidiasis, Bacterial skin infections, Cutaneous dermatophyte infection, Superficial Fungal skin infection
- Associated Therapies
- -
Evaluating the Safety and Tolerability of GDC-0349 in Patients With Locally Advanced or Metastatic Solid Tumors or Non Hodgkin's Lymphoma
- First Posted Date
- 2011-05-19
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Genentech, Inc.
- Target Recruit Count
- 10
- Registration Number
- NCT01356173
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