Tioconazole (Monistat Simple Therapy, Vagistat)

Overview

Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis.

Mechanism of Action

Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Tioconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.

Indications

For the local treatment of vulvovaginal candidiasis (moniliasis).

• Fungal skin infection
• Infection, Mixed
• Onychomycosis
• Vaginal Candidiasis
• Vulvovaginal Candidiasis
• Bacterial skin infections
• Cutaneous dermatophyte infection
• Superficial Fungal skin infection