Tioconazole

Overview

Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.

Indication

For the local treatment of vulvovaginal candidiasis (moniliasis).

Associated Conditions

Fungal skin infection
Infection, Mixed
Onychomycosis
Vaginal Candidiasis
Vulvovaginal Candidiasis
Bacterial skin infections
Cutaneous dermatophyte infection
Superficial Fungal skin infection

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Combined Fractional CO2 Laser With Topical Tioconazole Versus Q-switched Nd:YAG Laser in the Treatment of Onychomycosis; a Randomized Controlled Trial	2023/08/21	NCT05999474	Phase 4	Recruiting	Cairo University
Evaluating the Safety and Tolerability of GDC-0349 in Patients With Locally Advanced or Metastatic Solid Tumors or Non Hodgkin's Lymphoma	2011/05/19	NCT01356173	Phase 1	Completed	Genentech, Inc.

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
GYNO-ELLYCIE VAGINAL OINTMENT 6.5%	N/A	bright future pharmaceuticals factory o/b bright future pharmaceutical laboratories limited	N/A	N/A	6/8/2009

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
GYNECURE VAGINAL OVULE 300MG	pfizer canada inc., consumer healthcare division	02095009	Suppository - Vaginal	300 MG / SUP	12/31/1995
GYNECURE VAGINAL OINTMENT 6.5% W/W	pfizer canada inc., consumer healthcare division	02095017	Ointment - Vaginal	6.5 %	12/31/1995
TROSYD AF CREAM 1%	pfizer canada inc., consumer healthcare division	02095025	Cream - Topical	1 %	12/31/1987
GYNECURE TANDEMPK.VAG ONT6.5%/VULV.CRM1%-W/W	pfizer canada inc., consumer healthcare division	02218291	Cream , Ointment - Topical , Vaginal	1 % / KIT	3/27/1997
GYNECURE TANDEMPK.VAG ONT6.5%/VULV.CRM1%-W/W	pfizer canada inc., consumer healthcare division	02218291	Cream , Ointment - Topical , Vaginal	6.5 % / KIT	3/27/1997
GYNECURE TANDEMPK.VAG OV.300MG/VULV.CRM1%W/W	pfizer canada inc., consumer healthcare division	02218283	Cream , Suppository - Vaginal , Topical	1 % / KIT	12/2/1996
GYNECURE TANDEMPK.VAG OV.300MG/VULV.CRM1%W/W	pfizer canada inc., consumer healthcare division	02218283	Cream , Suppository - Vaginal , Topical	300 MG / KIT	12/2/1996
TROSYD J CREAM 1% W/W	pfizer canada inc., consumer healthcare division	02217406	Cream - Topical	10 MG / G	3/27/1997
GYNECURE COM.PK.VAG ONT6.5%VULVAR CRM1% W/W	pfizer canada inc., consumer healthcare division	02171902	Cream , Ointment - Topical , Vaginal	6.5 %	12/31/1995
GYNECURE COM.PK.VAG ONT6.5%VULVAR CRM1% W/W	pfizer canada inc., consumer healthcare division	02171902	Cream , Ointment - Topical , Vaginal	1 %	12/31/1995

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
SERNAX 280 mg/ml SOLUCION CUTANEA EFG	Laboratorios Serra Pamies S.A.	70801	SOLUCIÓN CUTÁNEA	Medicamento Sujeto A Prescripción Médica	Commercialized
TROSID 280 mg/ml BARNIZ DE UÑAS MEDICAMENTOSO	Pfizer S.L.	58758	BARNIZ DE UÑAS MEDICAMENTOSO	Medicamento Sujeto A Prescripción Médica	Commercialized
TIOCONAZOL KORHISPANA 280 mg/ml BARNIZ DE UÑAS MEDICAMENTOSO EFG	Korhispana S.L.	67439	BARNIZ DE UÑAS MEDICAMENTOSO	Medicamento Sujeto A Prescripción Médica	Commercialized
TIOCONAZOL ABAMED 28% SOLUCION CUTANEA	Abamed Pharma S.L.	67470	BARNIZ DE UÑAS MEDICAMENTOSO	Medicamento Sujeto A Prescripción Médica	Not Commercialized

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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