Trifluridine
- Generic Name
- Trifluridine
- Brand Names
- Lonsurf, Viroptic
- Drug Type
- Small Molecule
- Chemical Formula
- C10H11F3N2O5
- CAS Number
- 70-00-8
- Unique Ingredient Identifier
- RMW9V5RW38
- Background
Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to idoxuridine . It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity against Herpes simplex virus type 1 and ...
- Indication
用于Ⅰ及Ⅱ型单纯疱疹病毒、胞病毒、牛痘病毒、巨细胞病毒、带状疱疹病毒及耐阿昔洛韦的疱疹病毒的眼部感染。
- Associated Conditions
- Metastatic Colorectal Cancer (CRC), Metastatic Gastric Cancers, Metastatic Gastroesophageal Junction Adenocarcinoma, Primary keratoconjunctivitis caused by herpes simplex virus type 2, Recurrent epithelial keratitis caused by herpes simplex 2
- Associated Therapies
- -
A Study to Evaluate the Safety and Efficacy of Selinexor With or Without Pembrolizumab Versus Standard of Care in Previously Treated Metastatic Colorectal Cancer With RAS Mutations
- Conditions
- Interventions
- First Posted Date
- 2021-04-22
- Last Posted Date
- 2023-11-03
- Lead Sponsor
- Karyopharm Therapeutics Inc
- Target Recruit Count
- 13
- Registration Number
- NCT04854434
- Locations
- 🇺🇸
Christiana Care Health Services, Christiana Hospital, Newark, Delaware, United States
🇺🇸BRCR Global, Plantation, Florida, United States
🇺🇸Valkyrie Clinical Trials, Los Angeles, California, United States
Study Comparing the Pharmacokinetics of FTD as a Component of TAS-102 With FTD Alone
- First Posted Date
- 2013-06-04
- Last Posted Date
- 2024-06-27
- Lead Sponsor
- Taiho Oncology, Inc.
- Target Recruit Count
- 44
- Registration Number
- NCT01867866
- Locations
- 🇺🇸
South Texas Accelerated Research Therapeutics, LLC, San Antonio, Texas, United States
Evaluation of the Therapeutic Benefit of r-metHuIFN- Gamma in AIDS Patients With Disseminated Mycobacterium Avium-Intracellulare (MAI) Infection: A Multi-Centered Pilot Study
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Amgen
- Target Recruit Count
- 15
- Registration Number
- NCT00002037
- Locations
- 🇺🇸
New York Hosp - Cornell Med Ctr, New York, New York, United States
Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical Trifluridine
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-02
- Target Recruit Count
- 25
- Registration Number
- NCT00000635
- Locations
- 🇺🇸
University of Colorado Hospital CRS, Aurora, Colorado, United States
🇺🇸NY Univ. HIV/AIDS CRS, New York, New York, United States
🇺🇸Cook County Hosp. CORE Ctr., Chicago, Illinois, United States
Drug Development Updates
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