Clopidogrel
- Generic Name
- Clopidogrel
- Brand Names
- Duoplavin, Plavix, Zyllt, Clopidogrel BGR (previously Zylagren), Clopidogrel TAD, Clopidogrel ratiopharm, Clopidogrel Zentiva (previously Clopidogrel Winthrop), Clopidogrel Krka, Clopidogrel Krka d.d. (previously Zopya), Clopidogrel Teva (hydrogen sulphate), Clopidogrel HCS, Iscover, Grepid, Clopidogrel Taw Pharma (previously Clopidogrel Mylan), Clopidogrel Viatris (previously Clopidogrel Taw Pharma)
- Drug Type
- Small Molecule
- Chemical Formula
- C16H16ClNO2S
- CAS Number
- 113665-84-2
- Unique Ingredient Identifier
- A74586SNO7
- Background
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,
It has been shown to be superior to aspirin in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.
Clopidogrel was granted FDA approval on 17 November 1997.
- Indication
1.用于新近心肌梗死、新近脑卒中或确诊的周围动脉病变患者，可减少新的缺血性脑卒中、心肌梗死和死亡等心脑血管事件的符合终点；
2.用于急性冠状动脉综合征（不稳定心绞痛和非ST段抬高心肌梗死）患者；
3.用于冠状动脉支架置入术后预防支架内血栓形成（与阿司匹林联用）。
- Associated Conditions
- Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events
- Associated Therapies
- -
Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS
- First Posted Date
- 2015-04-14
- Last Posted Date
- 2015-04-14
- Target Recruit Count
- 75
- Registration Number
- NCT02415803
- Locations
- 🇺🇸
VerifyNow, San Diego, California, United States
Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy
- Conditions
- Interventions
- First Posted Date
- 2015-03-31
- Last Posted Date
- 2019-07-25
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 39
- Registration Number
- NCT02404363
- Locations
- 🇫🇷
Service d'oncologie digestive - Institut Sainte Catherine, Avignon, France
Genotype and Platelet Reactivity in Patients on Hemodialysis
- First Posted Date
- 2015-03-20
- Last Posted Date
- 2015-03-20
- Lead Sponsor
- Kyunghee University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT02394145
- Locations
- 🇰🇷
Kyung Hee University Hospital, Seoul, Korea, Republic of
Hip-Fracture Surgery on Patients in Clopidogrel Therapy
- First Posted Date
- 2015-03-18
- Last Posted Date
- 2015-03-18
- Lead Sponsor
- Hvidovre University Hospital
- Target Recruit Count
- 356
- Registration Number
- NCT02391883
Simplified Anti-Thrombotic Therapy for FFR
- Conditions
- Interventions
- First Posted Date
- 2015-03-10
- Last Posted Date
- 2017-02-03
- Lead Sponsor
- Odessa Heart Institute
- Target Recruit Count
- 300
- Registration Number
- NCT02384070
Effect of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation
- Conditions
- Interventions
- First Posted Date
- 2015-03-05
- Last Posted Date
- 2016-07-06
- Lead Sponsor
- Kiyuk Chang
- Target Recruit Count
- 38
- Registration Number
- NCT02379676
- Locations
- 🇰🇷
Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of
P3AMI Antiplatelet Trial
- First Posted Date
- 2015-03-03
- Last Posted Date
- 2020-02-10
- Lead Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
- Target Recruit Count
- 87
- Registration Number
- NCT02376283
- Locations
- 🇬🇧
The Royal Wolverhampton NHS Trust, Wolverhampton, West Midlands, United Kingdom
A Single-center, Prospective,Randomized Study of Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Dual Anti-platelet Therapy After Coronary Artery Bypass Grafting
- Conditions
- Interventions
- First Posted Date
- 2015-01-05
- Last Posted Date
- 2017-05-09
- Target Recruit Count
- 137
- Registration Number
- NCT02330640
- Locations
- 🇨🇳
FuWaiHospital, Beijing, Beijing, China
STEEL Percutaneous Coronary Intervention
- Conditions
- Interventions
- First Posted Date
- 2014-12-30
- Last Posted Date
- 2019-01-23
- Target Recruit Count
- 180
- Registration Number
- NCT02327624
- Locations
- 🇬🇧
Sheffield Teaching Hospitals NHS FT, Sheffield, United Kingdom
Comparison of Low-Dose, Standard-Dose Ticagrelor and Clopidogrel for Inhibition of Platelet Reactivity in Patients With Acute Coronary Syndromes
- First Posted Date
- 2014-12-18
- Last Posted Date
- 2017-06-16
- Lead Sponsor
- Seung-Jung Park
- Target Recruit Count
- 65
- Registration Number
- NCT02319941
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Songpa-gu, Korea, Republic of
Drug Development Updates
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