Clopidogrel

Generic Name: Clopidogrel

Brand Names: Duoplavin, Plavix, Zyllt, Clopidogrel BGR (previously Zylagren), Clopidogrel TAD, Clopidogrel ratiopharm, Clopidogrel Zentiva (previously Clopidogrel Winthrop), Clopidogrel Krka, Clopidogrel Krka d.d. (previously Zopya), Clopidogrel Teva (hydrogen sulphate), Clopidogrel HCS, Iscover, Grepid, Clopidogrel Taw Pharma (previously Clopidogrel Mylan), Clopidogrel Viatris (previously Clopidogrel Taw Pharma)

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₆ClNO_₂S

CAS Number: 113665-84-2

Unique Ingredient Identifier: A74586SNO7

Background: Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,

It has been shown to be superior to aspirin in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.

Clopidogrel was granted FDA approval on 17 November 1997.

Indication: 1.用于新近心肌梗死、新近脑卒中或确诊的周围动脉病变患者，可减少新的缺血性脑卒中、心肌梗死和死亡等心脑血管事件的符合终点；

2.用于急性冠状动脉综合征（不稳定心绞痛和非ST段抬高心肌梗死）患者；

3.用于冠状动脉支架置入术后预防支架内血栓形成（与阿司匹林联用）。

Associated Conditions: Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events

Associated Therapies: -

Clinical Trials

Effect of Different Anti-platelet Strategies on the Long-term Outcome After Sirolimus Drug-eluting Stent Implantation

Not Applicable

Conditions: Coronary Artery Disease

Interventions: Drug: clopidogrel
Drug: placebo
Drug: clopidogrel and placebo

First Posted Date: 2010-11-03

Last Posted Date: 2011-07-20

Lead Sponsor: Sir Run Run Shaw Hospital

Target Recruit Count: 5232

Registration Number: NCT01233167

An Interaction Study to Evaluate the Effect of Esomeprazole/Acetylsalicylic Acid on the Metabolism and Effect of Clopidogrel

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: Clopidogrel
Drug: Esomeprazole/ASA

First Posted Date: 2010-09-28

Last Posted Date: 2011-10-07

Lead Sponsor: AstraZeneca

Target Recruit Count: 58

Registration Number: NCT01210339

Locations: 🇸🇪
Research Site, Uppsala, Sweden

Additional Benefit of Cilostazol to Dual Antiplatelet Therapy After Biolimus-eluting Stent Implantation

Phase 4

Completed

Conditions: Coronary Artery Disease

Interventions: Drug: Cilostazol
Drug: Aspirin
Drug: Clopidogrel

First Posted Date: 2010-09-01

Last Posted Date: 2016-11-15

Lead Sponsor: Yonsei University

Target Recruit Count: 630

Registration Number: NCT01192724

Locations: 🇰🇷
Wonju Christian Hospital, Wonju, Gangwon, Korea, Republic of

Double the Dose of Clopidogrel or Switch to Prasugrel to Antagonize Proton Pump Inhibitor Interaction.

Not Applicable

Completed

Conditions: Anti Platelet Effects

Interventions: Drug: Prasugrel
Drug: Clopidogrel
Drug: Lansoprazole
Drug: Placebo

First Posted Date: 2010-08-04

Last Posted Date: 2012-07-04

Lead Sponsor: Ascopharm Groupe Novasco

Target Recruit Count: 82

Registration Number: NCT01175200

Locations: 🇫🇷
Pitié Salpétrière Hospital, Paris, France

Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping

Phase 4

Completed

Conditions: Cerebral Infarction

Interventions: Drug: Clopidogrel
Drug: Triflusal

First Posted Date: 2010-08-04

Last Posted Date: 2015-03-17

Lead Sponsor: Gangnam Severance Hospital

Target Recruit Count: 795

Registration Number: NCT01174693

Locations: 🇰🇷
Department of Neurology, Wonju Christian Hospital, Yonei University Wonju College of Medicine, Wonju-si, Gangwon-do, Korea, Republic of
🇰🇷
Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang-si, Gyeonggi-do, Korea, Republic of
🇰🇷
Department of Neurology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si, Gyeonggi-do, Korea, Republic of

and more 15 locations