Triflusal
- Generic Name
- Triflusal
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C10H7F3O4
- CAS Number
- 322-79-2
- Unique Ingredient Identifier
- 1Z0YFI05OO
- Background
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative. The benefits of this agent are the lack of action over the arachidonic acid pathway, the driven production of nitric oxide and the increase of cyclic nucleotide concentration on endothelial cells. The latest translates into the expansion of peripheral blood vessels. It is very important as a secondary prevention of ischemic stroke by offering a lower risk of bleeding. It was developed by J. Uriach and Company and even though it is commercialized in different countries it is not approved by the FDA, EMA or HealthCanada.
- Indication
Triflusal is indicated as prophylaxis of thromboembolic disorders. It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke and myocardial infarction.
- Associated Conditions
- Thromboembolism, Arterial thromboembolic disease
- Associated Therapies
- -
Influence of Triflusal on Cognitive Functions in Subjects Under Chronic Stress
- First Posted Date
- 2016-09-16
- Last Posted Date
- 2017-03-01
- Lead Sponsor
- Prof. Dominique de Quervain, MD
- Target Recruit Count
- 41
- Registration Number
- NCT02904109
- Locations
- 🇨🇭
University of Basel, Division of Cognitive Neuroscience, Basel, Switzerland
ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)
- First Posted Date
- 2015-11-30
- Last Posted Date
- 2018-04-17
- Lead Sponsor
- University of Ioannina
- Target Recruit Count
- 1220
- Registration Number
- NCT02616497
- Locations
- 🇬🇷
Atherothrombosis Research Centre / Laboratory of Biochemistry, University of Ioannina, Ioannina, Greece
Influence of Triflusal on Cognitive Functions in Healthy Subjects
- First Posted Date
- 2014-12-22
- Last Posted Date
- 2015-11-10
- Lead Sponsor
- Prof. Dominique de Quervain, MD
- Target Recruit Count
- 40
- Registration Number
- NCT02321852
- Locations
- 🇨🇭
University of Basel, Division of Cognitive Neuroscience, Basel, Switzerland
The Effect of Triflusal on Peripheral Microcirculation Dysfunction
- First Posted Date
- 2012-06-05
- Last Posted Date
- 2014-03-05
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 92
- Registration Number
- NCT01612273
- Locations
- 🇰🇷
Division of Cardiology, Department of Internal Medicine, severance hospital, Seoul, Korea, Republic of
Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping
- First Posted Date
- 2010-08-04
- Last Posted Date
- 2015-03-17
- Lead Sponsor
- Gangnam Severance Hospital
- Target Recruit Count
- 795
- Registration Number
- NCT01174693
- Locations
- 🇰🇷
Department of Neurology, Wonju Christian Hospital, Yonei University Wonju College of Medicine, Wonju-si, Gangwon-do, Korea, Republic of
🇰🇷Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang-si, Gyeonggi-do, Korea, Republic of
🇰🇷Department of Neurology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si, Gyeonggi-do, Korea, Republic of
Drug Development Updates
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