Midodrine

Generic Name: Midodrine

Brand Names: Proamatine

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈N_₂O_₄

CAS Number: 42794-76-3

Unique Ingredient Identifier: 6YE7PBM15H

Background: An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

Indication: For the treatment of symptomatic orthostatic hypotension (OH).

Associated Conditions: Symptomatic Orthostatic Hypotension

Associated Therapies: -

Clinical Trials

Use of Midodrine in Septic Shock Patients

Phase 2

Recruiting

Conditions: Low Blood Pressure
Sepsis

Interventions: Other: Standard of Care
Drug: Midodrine

First Posted Date: 2024-03-20

Last Posted Date: 2024-11-07

Lead Sponsor: Mayo Clinic

Target Recruit Count: 270

Registration Number: NCT06319248

Locations: 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States

Evaluation of Low-dose Albumin and Midodrine Versus Midodrine Alone in Outcome of Recurrent Ascites in Patients With Decompensated Cirrhosis.

Not Applicable

Not yet recruiting

Conditions: Decompensated Cirrhosis

Interventions: Drug: Midodrine
Drug: Albumin
Other: Standard of Care

First Posted Date: 2024-02-07

Last Posted Date: 2024-02-07

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 100

Registration Number: NCT06245590

Locations: 🇮🇳
Asian Institute of Gastroenterology, Somajiguda, Hyderabad, India
🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India

Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section: A Prospective Double-blind Randomized Clinical Trial

Not Applicable

Not yet recruiting

Conditions: Post Spinal Anesthesia Hypotension

Interventions: Drug: Midodrine
Drug: Norepinephrine

First Posted Date: 2024-01-19

Last Posted Date: 2024-01-19

Lead Sponsor: Sohag University

Target Recruit Count: 90

Registration Number: NCT06213935

Midodrine Plus Albumin Versus Midodrine Alone to Prevent Cirrhosis Related Complications in Children With Cirrhosis and Ascites

Not Applicable

Not yet recruiting

Conditions: Liver Cirrhosis

Interventions: Drug: Midodrine
Biological: albumin
Other: Standard Medical Treatment

First Posted Date: 2023-10-19

Last Posted Date: 2023-10-19

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 60

Registration Number: NCT06091345

Locations: 🇮🇳
Institute of Liver & Biliary Sciences (ILBS), New Delhi, Delhi, India

Efficacy and Safety of Midodrine in Refractory or Recurrent Ascites in Children With Cirrhosis.

Not Applicable

Withdrawn

Conditions: Refractory Ascites in Children With Cirrhosis

Interventions: Drug: Midodrine
Other: Standard medical treatment

First Posted Date: 2021-10-19

Last Posted Date: 2024-05-07

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Registration Number: NCT05084534

Locations: 🇮🇳
ILBS, New Delhi, India

Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)

Phase 4

Recruiting

Conditions: Vasoplegia

Interventions: Drug: Placebo
Drug: Midodrine

First Posted Date: 2021-09-28

Last Posted Date: 2024-01-18

Lead Sponsor: University of Alberta

Target Recruit Count: 350

Registration Number: NCT05058612

Locations: 🇨🇦
University of Alberta Hospital, Edmonton, Alberta, Canada

Evaluation of Albumin and Midodrine Versus Albumin Alone in Outcome of Refractory Ascites in Patients With Decompensated Cirrhosis.

Not Applicable

Conditions: Liver Cirrhosis

Interventions: Biological: Albumin
Drug: Midodrine
Other: Standard Medical Treatment
Other: Placebo

First Posted Date: 2021-03-25

Last Posted Date: 2021-06-15

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 200

Registration Number: NCT04816240

Locations: 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India

Midodrine as Novel Treatment of Post-Cardiopulmonary Bypass Vasoplegic Syndrome

Phase 4

Terminated

Conditions: Use of Midodrine in Post-cardiopulmonary Bypass Vasoplegic Syndrome

Interventions: Drug: Midodrine
Drug: Methylcellulose

First Posted Date: 2020-12-16

Last Posted Date: 2022-07-01

Lead Sponsor: Medstar Health Research Institute

Target Recruit Count: 10

Registration Number: NCT04668859

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Early Phase 1

Recruiting

Conditions: Pure Autonomic Failure
Autonomic Failure
Neurogenic Orthostatic Hypotension
Multiple System Atrophy
Parkinson Disease

Interventions: Drug: Midodrine
Drug: Placebo pill
Device: sham compression
Device: Abdominal compression

First Posted Date: 2020-11-09

Last Posted Date: 2024-03-26

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 31

Registration Number: NCT04620382

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Midodrine and Albumin in Patients With Refractory Ascites

Phase 3

Conditions: Refractory Ascites

Interventions: Drug: Albumin
Drug: Standard medical therapy (SMT)
Drug: Midodrine

First Posted Date: 2020-11-09

Last Posted Date: 2020-11-09

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 114

Registration Number: NCT04621617

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy