Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Optimum Misoprostol Dose Prior to Office Hysteroscopy
- Conditions
- Interventions
- First Posted Date
- 2012-06-05
- Last Posted Date
- 2013-04-11
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 132
- Registration Number
- NCT01612065
- Locations
- 🇪🇬
Kasr alainy hospital, faculty of medicine , Cairo university, Cairo, Egypt
Cervical Priming Before Dilation & Evacuation
- First Posted Date
- 2012-05-14
- Last Posted Date
- 2013-11-07
- Lead Sponsor
- Ibis Reproductive Health
- Target Recruit Count
- 159
- Registration Number
- NCT01597726
- Locations
- 🇿🇦
Tygerberg Hospital, Cape Town, South Africa
Combined Use of Oxytocin and Misoprostol Versus Oxytocin Infusion and Misoprostol Alone to Reduce Blood Loss at Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2012-04-05
- Last Posted Date
- 2012-10-11
- Lead Sponsor
- Qazvin University Of Medical Sciences
- Target Recruit Count
- 150
- Registration Number
- NCT01571323
- Locations
- 🇮🇷
Qazvin Medical University Science, Qazvin, Iran, Islamic Republic of
Sublingual Misoprostol Versus Standard Surgical Care for the Treatment of Incomplete Abortion in Nigeria
- Conditions
- Interventions
- First Posted Date
- 2012-02-27
- Last Posted Date
- 2012-02-27
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 90
- Registration Number
- NCT01539408
- Locations
- 🇳🇬
Adeoyo Maternity Hospital, Ibadan, Nigeria
🇳🇬University College Hospital, Ibadan, Ibadan, Nigeria
A Study of Self-administered Misoprostol to Prevent Bleeding After Childbirth in the Community (MamaMiso)
- First Posted Date
- 2012-01-16
- Last Posted Date
- 2013-03-13
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 749
- Registration Number
- NCT01510574
- Locations
- 🇺🇬
Busiu Health Centre, Mbale, Uganda
🇺🇬Lwangoli Health Centre, Mbale, Uganda
🇺🇬Siira Health Centre, Mbale, Uganda
Misoprostol for Treatment of Postpartum Haemorrhage (PPH) in Home Births
- Conditions
- Interventions
- First Posted Date
- 2012-01-12
- Last Posted Date
- 2016-07-11
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 70
- Registration Number
- NCT01508429
- Locations
- 🇦🇫
Home delivery setting, Darwaz, Ishkashim, Shugnan, Wakhan districts, Badakshan Province, Afghanistan
A Novel Protocol for Labour Induction
- Conditions
- Interventions
- First Posted Date
- 2012-01-10
- Last Posted Date
- 2014-01-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 400
- Registration Number
- NCT01506388
- Locations
- 🇪🇬
Waleed El-khayat, Cairo, Egypt
🇪🇬Cairo University, Cairo, Egypt
Treatment of Postpartum Haemorrhage (PPH) Using Misoprostol in Home Births
- First Posted Date
- 2011-12-05
- Last Posted Date
- 2016-03-10
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 84
- Registration Number
- NCT01485562
- Locations
- 🇵🇰
Home Births, Chitral, Khyber Pakhtunkhwa, Pakistan
Comparative of Effects of Sublingual Misoprostol and Infusion Oxytocin in Reduction of Bleeding at Cesarean
- First Posted Date
- 2011-11-23
- Last Posted Date
- 2011-12-13
- Lead Sponsor
- Soudabeh Eshghi ali
- Target Recruit Count
- 180
- Registration Number
- NCT01477840
- Locations
- 🇮🇷
KUMS Obstetrics & Gynecology Department, Imam Reza Hospital, Kermanshah, Iran, Islamic Republic of
Study on Combined Use of Letrozole, Mifepristone and Misoprostol in Termination of Pregnancy
- Conditions
- Interventions
- First Posted Date
- 2011-11-21
- Last Posted Date
- 2011-11-21
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 50
- Registration Number
- NCT01475318
- Locations
- 🇭🇰
Joyce Chai, Hong Kong, Hong Kong
Drug Development Updates
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