Mifepristone
- Generic Name
- Mifepristone
- Brand Names
- Korlym, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C29H35NO2
- CAS Number
- 84371-65-3
- Unique Ingredient Identifier
- 320T6RNW1F
- Background
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary c...
- Indication
For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.
- Associated Conditions
- Hyperglycemia
- Associated Therapies
- Medically induced abortion
Letrozole Versus Mifepristone and Misoprostol in Silent Miscarriage
- Conditions
- Interventions
- First Posted Date
- 2024-12-13
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 884
- Registration Number
- NCT06733727
Mifepristone vs Misoprostol
- First Posted Date
- 2024-07-16
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 94
- Registration Number
- NCT06502158
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Assessing the Efficacy and Acceptability of Two Missed Period Pills Regimens
- Conditions
- Interventions
- First Posted Date
- 2024-07-09
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 286
- Registration Number
- NCT06492889
A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2023-10-25
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 201
- Registration Number
- NCT06099769
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸University of California San Francisco (Data collection only), San Francisco, California, United States
🇺🇸University of Chicago Medical Center, Chicago, Illinois, United States
The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy
- Conditions
- Interventions
- First Posted Date
- 2022-04-22
- Last Posted Date
- 2023-10-17
- Lead Sponsor
- KK Women's and Children's Hospital
- Target Recruit Count
- 144
- Registration Number
- NCT05341817
- Locations
- 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
- First Posted Date
- 2022-04-11
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 30
- Registration Number
- NCT05322252
- Locations
- 🇺🇸
Barnes-Jewish Hospital, Saint Louis, Missouri, United States
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
- First Posted Date
- 2022-03-31
- Last Posted Date
- 2023-09-06
- Lead Sponsor
- Calcutta National Medical College and Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05304273
- Locations
- 🇮🇳
Calcutta National Medical College and Hospital, Kolkata, West Bengal, India
RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma
- Conditions
- Interventions
- First Posted Date
- 2022-02-01
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Target Recruit Count
- 158
- Registration Number
- NCT05217758
- Locations
- 🇳🇱
Amsterdam UMC, location VUmc, Amsterdam, Noord-Holland, Netherlands
Mifepristone Outpatient Labour Induction
- First Posted Date
- 2022-01-04
- Last Posted Date
- 2023-09-06
- Lead Sponsor
- Chelsea and Westminster NHS Foundation Trust
- Target Recruit Count
- 400
- Registration Number
- NCT05177510
- Locations
- 🇬🇧
Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
🇬🇧West Middlesex University Hospital, Isleworth, United Kingdom
🇬🇧Chelsea and Westminster Hospital, London, United Kingdom
Long-term Use of Mifepristone in the Treatment of Adenomyosis
- Conditions
- Interventions
- First Posted Date
- 2021-12-09
- Last Posted Date
- 2021-12-09
- Target Recruit Count
- 140
- Registration Number
- NCT05151016
- Locations
- 🇨🇳
Women's Hospital of Zhejiang Medical University, Hangzhou, Zhejiang, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.