Mifepristone
- Generic Name
- Mifepristone
- Brand Names
- Korlym, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C29H35NO2
- CAS Number
- 84371-65-3
- Unique Ingredient Identifier
- 320T6RNW1F
- Background
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary c...
- Indication
For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.
- Associated Conditions
- Hyperglycemia
- Associated Therapies
- Medically induced abortion
INIA Stress and Chronic Alcohol Interactions: Glucocorticoid Antagonists in Heavy Drinkers
- First Posted Date
- 2016-12-12
- Last Posted Date
- 2024-05-24
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 65
- Registration Number
- NCT02989662
- Locations
- 🇺🇸
Integrated Program for Substance Abuse Research, Baltimore, Maryland, United States
Acceptability and Feasibility of Medical Abortion in Singapore
- First Posted Date
- 2016-12-07
- Last Posted Date
- 2018-04-06
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 130
- Registration Number
- NCT02985229
- Locations
- 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore
🇸🇬National University Hospital, Singapore, Singapore
Acceptability and Feasibility of a Simplified Medical Abortion Service Delivery in Western Ukraine
- First Posted Date
- 2016-12-02
- Last Posted Date
- 2018-06-18
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 102
- Registration Number
- NCT02981030
- Locations
- 🇺🇦
Vinnitsa Regional Clinical Hospital, Vinnitsa, Ukraine
🇺🇦Lviv Municipal Women's Consultation No. 2, L'viv, Ukraine
Abraxane® With or Without Mifepristone for Advanced, Glucocorticoid Receptor-Positive, Triple-Negative Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2016-06-02
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 29
- Registration Number
- NCT02788981
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
🇺🇸Northshore University HealthSystem, Evanston, Illinois, United States
🇺🇸Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Medical Abortion at Gestational Age of 8 to ≤9 Weeks Versus >9 to ≤12 Weeks
- First Posted Date
- 2016-04-20
- Last Posted Date
- 2016-06-20
- Lead Sponsor
- Ibis Reproductive Health
- Target Recruit Count
- 648
- Registration Number
- NCT02745093
- Locations
- 🇲🇽
Marie Stopes Mexico Azcapotzalco, Del. Azcapotzalco, Mexico Distrito Federal, Mexico
🇲🇽Marie Stopes Mexico Pedregal, Del. Tlalpan, Mexico Distrito Federal, Mexico
🇲🇽Marie Stopes Mexico Roma, Del. Cuauhtémoc, Mexico Distrito Federal, Mexico
A Pilot of an Outpatient Regimen of Medical Abortion With Mifepristone and Sublingual Misoprostol in the 11 and 12 Weeks
- Conditions
- Interventions
- First Posted Date
- 2016-03-28
- Last Posted Date
- 2016-03-28
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 50
- Registration Number
- NCT02720991
A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion
- First Posted Date
- 2016-03-15
- Last Posted Date
- 2016-07-14
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 320
- Registration Number
- NCT02708446
- Locations
- 🇺🇿
Clinic No. 2, Tashkent Medical Academy, Tashkent, Uzbekistan
🇦🇲b. Republican Institute of Reproductive Health, Perinatology, Obstetrics and Gynecology (RIRHPOG), Yerevan, Armenia
🇳🇵Kathmandu Medical College, Kathmandu, Nepal
Non-surgical Alternatives to Treatment of Failed Medical Abortion
- Conditions
- Interventions
- First Posted Date
- 2016-03-10
- Last Posted Date
- 2021-07-26
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 16
- Registration Number
- NCT02704481
- Locations
- 🇺🇸
Planned Parenthood of Northern California, Concord, California, United States
🇺🇸Presidential Women's Center, West Palm Beach, Florida, United States
🇺🇸Family Planning Associates Medical Group, Ltd., Chicago, Illinois, United States
Mifepristone Versus Osmotic Dilators in Conjunction With Misoprostol for Cervical Preparation Prior to D&E at 14-19 Weeks
- Conditions
- Interventions
- First Posted Date
- 2016-02-10
- Last Posted Date
- 2019-09-19
- Lead Sponsor
- Stanford University
- Registration Number
- NCT02679092
- Locations
- 🇺🇸
Planned Parenthood Mar Monte, San Jose, California, United States
Mifepristone for Breast Cancer Patients With Higher Levels of Progesterone Receptor Isoform A Than Isoform B.
- First Posted Date
- 2016-01-11
- Last Posted Date
- 2022-05-06
- Lead Sponsor
- Hospital Provincial Magdalena V. de Martínez
- Target Recruit Count
- 20
- Registration Number
- NCT02651844
- Locations
- 🇦🇷
HospitalPMVM, General Pacheco, Buenos Aires, Argentina
Drug Development Updates
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