Mifepristone
- Generic Name
- Mifepristone
- Brand Names
- Korlym, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C29H35NO2
- CAS Number
- 84371-65-3
- Unique Ingredient Identifier
- 320T6RNW1F
- Background
Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).
- Indication
For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.
- Associated Conditions
- Hyperglycemia
- Associated Therapies
- Medically induced abortion
Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer.
- Conditions
- Breast Cancer Female
- Interventions
- Drug: Standard therapyDrug: 9 cis retinoic acid
- First Posted Date
- 2021-08-23
- Last Posted Date
- 2021-08-23
- Lead Sponsor
- Mahmoud Ramadan mohamed Elkazzaz
- Target Recruit Count
- 160
- Registration Number
- NCT05016349
Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills"
- First Posted Date
- 2020-12-21
- Last Posted Date
- 2021-08-12
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 139
- Registration Number
- NCT04676776
- Locations
- 🇲🇽
Cuidado Integral de la Mujer, Gineclinic, S.C, Mexico City, Mexico
Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency
- First Posted Date
- 2020-10-19
- Last Posted Date
- 2023-06-12
- Lead Sponsor
- Tobias Else
- Target Recruit Count
- 3
- Registration Number
- NCT04588688
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Improving Access to Abortion in the Republic of Georgia
- First Posted Date
- 2020-07-07
- Last Posted Date
- 2020-07-07
- Lead Sponsor
- Center for Information and Counseling on Reproductive Health - Tanadgoma
- Target Recruit Count
- 120
- Registration Number
- NCT04458558
- Locations
- 🇬🇪
Batumi Medical Center, Batumi, Georgia
🇬🇪Clinic Elite, Zestap'oni, Georgia
🇬🇪David Gagua Clinic, Tbilisi, Georgia
Understanding GWI: Integrative Modeling
- Conditions
- Gulf War IllnessPersian Gulf SyndromeOccupational Diseases
- Interventions
- First Posted Date
- 2020-02-05
- Last Posted Date
- 2020-02-05
- Lead Sponsor
- South Florida Veterans Affairs Foundation for Research and Education
- Target Recruit Count
- 20
- Registration Number
- NCT04255498
- Locations
- 🇺🇸
Miami VA Healthcare System, Miami, Florida, United States
TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset
- Conditions
- Gulf War Illness
- Interventions
- First Posted Date
- 2020-02-05
- Last Posted Date
- 2025-02-19
- Lead Sponsor
- Nova Southeastern University
- Target Recruit Count
- 20
- Registration Number
- NCT04254627
- Locations
- 🇺🇸
Nova Southeastern University, Davie, Florida, United States
🇺🇸Miami VA Healthcare System, Miami, Florida, United States
Pilot Study of an Ambulatory Medical Abortion Service at 13-18 Weeks of Gestation in Colombia
- Conditions
- Second Trimester Abortion
- Interventions
- First Posted Date
- 2019-08-21
- Last Posted Date
- 2021-07-23
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 16
- Registration Number
- NCT04063904
- Locations
- 🇨🇴
Fundacion Orientame, Bogotá, Colombia
Assessing Medical Menstrual Regulation in the United States
- First Posted Date
- 2019-06-03
- Last Posted Date
- 2021-03-24
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 284
- Registration Number
- NCT03972358
- Locations
- 🇺🇸
Carafem Health Center, Chevy Chase, Maryland, United States
Mail Order Mifepristone Study
- First Posted Date
- 2019-04-12
- Last Posted Date
- 2024-08-14
- Lead Sponsor
- Daniel Grossman, MD
- Target Recruit Count
- 536
- Registration Number
- NCT03913104
- Locations
- 🇺🇸
Delaware County Women's Center, Chester, Pennsylvania, United States
🇺🇸Christiana Care Health System, Wilmington, Delaware, United States
🇺🇸Highland Hospital, Oakland, California, United States
Blocking Mifepristone Action With Progesterone
- Conditions
- Pregnancy, Unwanted
- Interventions
- First Posted Date
- 2018-12-13
- Last Posted Date
- 2020-01-22
- Lead Sponsor
- University of California, Davis
- Target Recruit Count
- 12
- Registration Number
- NCT03774745
- Locations
- 🇺🇸
Planned Parenthood Mar Monte, Sacramento, California, United States
🇺🇸Family Planning Associates, Sacramento, California, United States
🇺🇸University of California, Davis, Sacramento, California, United States
Drug Development Updates
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