Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy

Phase 3
Completed
Conditions
Blood Loss, Surgical
Uterine Myoma
Interventions
Drug: Misoprostol
First Posted Date
2021-11-05
Last Posted Date
2021-11-05
Lead Sponsor
Pak Emirates Military Hospital
Target Recruit Count
200
Registration Number
NCT05108597
Locations
🇵🇰

PEMH, Rawalpindi, Punjab, Pakistan

Mifepristone for Labor Induction

First Posted Date
2021-10-28
Last Posted Date
2024-07-31
Lead Sponsor
Stanford University
Target Recruit Count
30
Registration Number
NCT05097326
Locations
🇺🇸

Lucile Packard Children's Hospital, Palo Alto, California, United States

A Trial of Sublingual Misoprostol to Reduce Primary Postpartum Haemorrhage After Vaginal Delivery

First Posted Date
2021-10-15
Last Posted Date
2022-03-03
Lead Sponsor
The University of Hong Kong
Target Recruit Count
1300
Registration Number
NCT05079061

Oxytocin Versus, Sublingual Misoprostol in the Secondary Prevention of Postpartum Hemorrhage After Vaginal Delivery

Not Applicable
Conditions
Labor Complication
Interventions
Drug: misoprostol
Drug: oxytocin
First Posted Date
2021-10-14
Last Posted Date
2021-10-22
Lead Sponsor
Aswan University Hospital
Target Recruit Count
150
Registration Number
NCT05077540

Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion

First Posted Date
2021-08-04
Last Posted Date
2021-08-04
Lead Sponsor
Ain Shams University
Target Recruit Count
24
Registration Number
NCT04989400
Locations
🇪🇬

Ain SHams Maternity Hospital, Cairo, Abbaseya, Egypt

Missed Period Pill Study

Phase 4
Active, not recruiting
Conditions
Menstrual Regulation
Menstrual Irregularity
Interventions
Drug: Misoprostol
First Posted Date
2021-06-25
Last Posted Date
2024-10-03
Lead Sponsor
University of California, San Francisco
Target Recruit Count
100
Registration Number
NCT04940013
Locations
🇺🇸

University of California, San Francisco, Fresno, California, United States

Misoprostol Prior to Intrauterine Device Insertion

Not Applicable
Completed
Conditions
IUD
Interventions
Device: IUD
Drug: Misoprostol
First Posted Date
2021-06-21
Last Posted Date
2023-05-03
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT04932382
Locations
🇪🇬

Women Health Hospital - Assiut university, Assiut, Egypt

To Study the Efficacy and Safety of Misoprostol by Sublingual Routes for Induction of Labour

Not Applicable
Conditions
Induction of Labour
Interventions
Drug: Misoprostol
First Posted Date
2021-05-14
Last Posted Date
2021-05-17
Lead Sponsor
Ministry of Health, Bhutan
Target Recruit Count
500
Registration Number
NCT04887493
Locations
🇧🇹

Phuentsholing Hospital, Phuentsholing, Bhutan

Efficacy of Misoprostol in Prevention of Neonatal Respiratory Morbidity in Parturient at Early Term Elective Caesarian Section

First Posted Date
2021-03-03
Last Posted Date
2021-03-03
Lead Sponsor
Ain Shams University
Target Recruit Count
210
Registration Number
NCT04780412
Locations
🇪🇬

Ain Shams University - Faculty of Medicine, Cairo, Egypt

Misoprostol for Bloating and Distension

Early Phase 1
Withdrawn
Conditions
Distension
Gas Bloat Syndrome
Constipation
Interventions
Drug: Misoprostol
First Posted Date
2021-02-24
Last Posted Date
2023-09-28
Lead Sponsor
Montefiore Medical Center
Registration Number
NCT04768010
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