Misoprostol

Generic Name
Misoprostol
Brand Names
Arthrotec, Cytotec, Mifegymiso
Drug Type
Small Molecule
Chemical Formula
C22H38O5
CAS Number
59122-46-2
Unique Ingredient Identifier
0E43V0BB57
Background

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication

Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions
Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
Associated Therapies
Induction of cervix ripening therapy, Medically induced abortion
Clinical Trials
Related News

Oral Tranexamic Acid Plus Sublingual Misoprostol in Atonic Postpartum Hemorrhage

Not Applicable
Completed
Conditions
Post Partum Hemorrhage
Interventions
Drug: Carbetocin
Drug: misoprostol
Drug: TA
First Posted Date
2019-03-12
Last Posted Date
2021-09-29
Lead Sponsor
Aswan University Hospital
Target Recruit Count
135
Registration Number
NCT03870256
Locations
🇪🇬

AswanUH, Aswan, Egypt

Oral Misoprostol Solution in Comparison to Vaginal Misoprostol in Induction of Labor

Not Applicable
Conditions
Normal Vaginal Delivery
Interventions
Drug: Misoprostol
First Posted Date
2019-03-05
Last Posted Date
2019-03-05
Lead Sponsor
Ain Shams University
Target Recruit Count
100
Registration Number
NCT03863392
Locations
🇪🇬

Ainshams University, Cairo, Egypt

Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date Women

First Posted Date
2019-02-26
Last Posted Date
2019-03-12
Lead Sponsor
Abdelrahman Ali Fadel Youssef Mohamed
Target Recruit Count
100
Registration Number
NCT03854383
Locations
🇪🇬

Ain Shams maternity hospital, Cairo, Egypt

Obesity Study to Assess Induction of Labor

Not Applicable
Withdrawn
Conditions
Induction of Labor Affected Fetus / Newborn
Interventions
Drug: Misoprostol
First Posted Date
2019-01-08
Last Posted Date
2022-03-22
Lead Sponsor
University of Maryland, Baltimore
Registration Number
NCT03796416

Vaginal Misoprostol Before Intrauterine Contraceptive Device Insertion

Phase 3
Completed
Conditions
Contraception
Interventions
Drug: Placebos
Drug: Misoprostol
First Posted Date
2018-12-31
Last Posted Date
2018-12-31
Lead Sponsor
Ain Shams University
Target Recruit Count
90
Registration Number
NCT03790371
Locations
🇪🇬

AinShams university maternity hospital, Cairo, Abbassya, Egypt

Buccal Misoprostol and Intravenous Tranexamic Acid During Emergent Cesarean Delivery

First Posted Date
2018-12-17
Last Posted Date
2019-02-18
Lead Sponsor
hany farouk
Target Recruit Count
300
Registration Number
NCT03777696
Locations
🇪🇬

Aswan University, Aswan, Egypt

Sublingual Misoprostol and Tranexamic Acid in Pregnant Women With Twin Pregnancy Undergoing Cesarean Section

First Posted Date
2018-12-13
Last Posted Date
2019-02-15
Lead Sponsor
Aswan University Hospital
Target Recruit Count
150
Registration Number
NCT03774524
Locations
🇪🇬

Aswan University, Aswan, Egypt

Sublingual Misoprostol With or Without Intravenous Tranexamic Acid During Hemorrhagic Cesarean Section

First Posted Date
2018-12-13
Last Posted Date
2019-02-18
Lead Sponsor
Aswan University Hospital
Target Recruit Count
150
Registration Number
NCT03774706
Locations
🇪🇬

Aswan University, Aswan, Egypt

Cervical Ripening in Obese Women: Efficacy of 25 mcg Versus 50 mcg of Misoprostol

First Posted Date
2018-11-20
Last Posted Date
2018-11-20
Lead Sponsor
University of Cincinnati
Target Recruit Count
300
Registration Number
NCT03748147

Intrauterine Misoprostol Versus Rectal Misoprostol in Reducing Blood Loss During Cesarean Section

Phase 2
Conditions
Hemorrhage, Postpartum
Interventions
Drug: Misoprostol
First Posted Date
2018-10-29
Last Posted Date
2020-03-18
Lead Sponsor
Cairo University
Target Recruit Count
98
Registration Number
NCT03723031
Locations
🇪🇬

Faculty of medicine - Cairo university, Cairo, Egypt

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