甲苯咪唑 (Emverm, Vermox)

概览

Mebendazole is a benzimidazole anthelmintic used to treat helminth infections.

作用机制

Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

适应症

For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

• Ancylostoma caninum infection
• Ancylostoma duodenale infection
• Ascaris lumbricoides infection
• Capillariasis
• Enterobius vermicularis infection
• Filariasis
• Giardiasis
• Necatoriasis due to necator americanus
• Strongyloides Stercoralis Infection
• Taenia solium infection
• Toxocariasis
• Whipworm infection