MedPath

Betamethasone

Generic Name
Betamethasone
Brand Names
Betaderm, Betaloan Suik, Beteflam, Celestoderm, Celestone Soluspan, Dermacinrx Therazole Pak, Diprolene, Diprosalic, Diprosone, Dovobet, Enstilar, Fucibet, Lotriderm, Lotrisone, Luxiq, Marbeta, Rivasone, Rolene, Rosone, Sernivo, Taclonex, Valisone-G, Wynzora
Drug Type
Small Molecule
Chemical Formula
C22H29FO5
CAS Number
378-44-9
Unique Ingredient Identifier
9842X06Q6M
Background

Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.

Indication

As a member of the corticosteroid family, betamethasone is indicated for the treatment of several inflammatory conditions. As topical monotherapy, betamethasone is indicated to relieve pruritic and inflammatory symptoms of corticosteroid-responsive-dermatoses. Betamethasone can be used topically in combination with a vitamin D analog such as calcipotriene to treat plaque psoriasis. The corticosteroid is also available as an injectable suspension and can be used to manage a range of inflammatory conditions including endocrine disorders, gastrointestinal disorders, and rheumatic disorders among other conditions.

Associated Conditions
Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Atopic Dermatitis, Berylliosis, Blepharitis allergic, Blepharoconjunctivitis, Bullous dermatitis herpetiformis, Bursitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Dermatomyositis (DM), Dermatosis, Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Episcleritis, External ear inflammation, Eye allergy, Hypercalcemia of Malignancy, Inflammatory Reaction of the ear, Iridocyclitis, Iritis, Itching caused by Allergies, Keloids Scars, Keratitis, Keratitis interstitial, Keratoconjunctivitis, Leukemias, Lichen Planus (LP), Lichen simplex chronicus, Lupus Erythematosus, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Nephrotic Syndrome, Ocular Inflammation, Ocular injuries, Ophthalmia, Sympathetic, Pemphigus, Plaque psoriasis of the body, Plaque psoriasis of the scalp, Polymyositis, Post Surgical Ocular Inflammation, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriatic Arthritis, Psoriatic plaque, Pulmonary Tuberculosis (TB), Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Scleritis, Secondary thrombocytopenia, Severe Asthma, Severe Atopic Dermatitis, Skin Infections, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Verrucous Lichen Planus (LP), Acquired immune hemolytic anemia, Acute nonspecific tenosynovitis, Acute rheumatic carditis, Bacterial blepharitis, Corticosteroid-responsive dermatoses, Eczematous rash, Exfoliative erythroderma, Granuloma annulare lesions, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Allergic rhinitis, Severe Contact dermatitis, Severe Serum sickness, Severe Transfusion Reactions, Severe drug hypersensitivity reactions, Superficial ocular infections, Symptomatic Sarcoidosis, Synovitis of osteoarthritis
Associated Therapies
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Comparison of Ozone and Steroid Injection in Patients With Greater Trochanteric Pain Syndrome

Not Applicable
Completed
Conditions
Trochanteric Bursitis
Interventions
First Posted Date
2020-06-09
Last Posted Date
2021-10-21
Lead Sponsor
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Target Recruit Count
63
Registration Number
NCT04420572
Locations
🇹🇷

Sultan 2.Abdülhamid Han Training and Research Hospital, Istanbul, Eyalet/Yerleşke, Turkey

ACTH vs Betamethasone in Hospitalized Patients With Acute Gout

Not Applicable
Conditions
Gout Attack
Interventions
First Posted Date
2020-03-13
Last Posted Date
2020-03-13
Lead Sponsor
University of Patras
Target Recruit Count
60
Registration Number
NCT04306653
Locations
🇬🇷

University Hospital of Patras, PAtras, Achaia, Greece

Antenatal Betamethasone and the Risk of Neonatal Hypoglycemia

Conditions
Hypoglycemia
Interventions
First Posted Date
2018-10-11
Last Posted Date
2018-10-11
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
1000
Registration Number
NCT03702959
Locations
🇮🇱

Rambam health care campus, Haifa, Israel

Safety, Tolerability And Efficacy Study Of Topical PF-06763809 In Subjects With Mild To Moderate Chronic Plaque Psoriasis

Phase 1
Completed
Conditions
Psoriasis
Interventions
Drug: PF-06763809
Other: Vehicle
Drug: Calcipotriene/calcipotriol
Drug: Betamethasone
First Posted Date
2018-03-19
Last Posted Date
2020-06-25
Lead Sponsor
Pfizer
Target Recruit Count
18
Registration Number
NCT03469336
Locations
🇩🇪

bioskin GmbH, Hamburg, Germany

🇩🇪

Rothaar Studien GmbH, Berlin, Germany

A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT)

Phase 4
Conditions
Addison Disease
Interventions
First Posted Date
2017-07-07
Last Posted Date
2021-04-20
Lead Sponsor
Göteborg University
Target Recruit Count
30
Registration Number
NCT03210545
Locations
🇸🇪

Centrum for Endocrinology and Metabolism, Sahlgenska University Hospital, Gothenburg, Sweden

Effectiveness of Cortisone Injection and Splinting for Trigger Finger

Phase 4
Conditions
Trigger Finger
Interventions
Other: Splint
Combination Product: Splint + Cortico-steroid injection
Drug: Betamethasone
First Posted Date
2017-05-17
Last Posted Date
2021-03-01
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
120
Registration Number
NCT03156829
Locations
🇨🇦

Lawson Health Research Institute, London, Ontario, Canada

Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus

Phase 2
Conditions
Oral Lichen Planus
Interventions
First Posted Date
2017-01-20
Last Posted Date
2018-03-14
Lead Sponsor
Garlapati Komali
Target Recruit Count
30
Registration Number
NCT03026478
Locations
🇮🇳

Komali Garlapati, Hyderabad, Telangana, India

Effect of Antenatal Steroid on Pulmonary Artery Blood Flow

Phase 4
Conditions
Neonatal Respiratory Distress
Interventions
First Posted Date
2016-12-01
Last Posted Date
2017-11-17
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
126
Registration Number
NCT02978976
Locations
🇪🇬

11562, Cairo, Egypt

Vasoconstriction Trial With LEO 90100 Aerosol Foam

Phase 1
Completed
Conditions
Psoriasis Vulgaris
Interventions
Drug: LEO 90100 aerosol foam
Drug: Dermoval®/Dermovate®
Drug: Diprosone
Drug: Elocon
Drug: Locoid
Other: LEO 90100 foam vehicle
First Posted Date
2016-11-25
Last Posted Date
2017-05-09
Lead Sponsor
LEO Pharma
Target Recruit Count
36
Registration Number
NCT02973776
Locations
🇫🇷

CPCAD, Nice, Cedex, France

Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?

Phase 2
Terminated
Conditions
PPROM
Respiratory Distress Syndrome in Premature Infants
Interventions
Drug: Betamethasone
Drug: Placebo
First Posted Date
2016-10-20
Last Posted Date
2024-01-26
Lead Sponsor
The University of Texas Medical Branch, Galveston
Target Recruit Count
33
Registration Number
NCT02939742
Locations
🇺🇸

University of Texas Medical Branch in Galveston, Galveston, Texas, United States

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