Corticotropin

Generic Name: Corticotropin

Brand Names: Acthar, Cortrophin

Drug Type: Biotech

CAS Number: 12427-33-7

Unique Ingredient Identifier: K0U68Q2TXA

Background: Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

Indication: For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.

Purified corticotropin for injection is indicated for a variety of allergic and autoimmune conditions.

Associated Conditions: Acute Gouty Arthritis, Allergic Conjunctivitis (AC), Ankylosing Spondylitis (AS), Atopic Dermatitis, Chorioretinitis, Choroiditis, Infantile Spasms (IS), Iridocyclitis, Iritis, Keratitis, Multiple sclerosis exacerbation, Optic Neuritis, Polymyositis, Psoriatic Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Serum Sickness, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Anterior eye segment inflammation, Severe Erythema multiforme, Severe Psoriasis, Symptomatic Sarcoidosis, Systemic Dermatomyositis

Clinical Trials

Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

Phase 4

Recruiting

Conditions: Autoimmune Diseases
Dry Eye
Neurotrophic Keratitis

Interventions: Drug: Acthar Gel 80 UNT/ML Injectable Solution

First Posted Date: 2025-05-09

Last Posted Date: 2025-05-11

Lead Sponsor: Toyos Clinic

Target Recruit Count: 20

Registration Number: NCT06964269

Locations: 🇺🇸
Toyos Clinic, Nashville, Tennessee, United States

A Study of Acthar Gel Alone or With Tacrolimus to Reduce Proteinuria in Fibrillary Glomerulopathy Patients

Phase 4

Active, not recruiting

Conditions: Fibrillary Glomerulonephritis

Interventions: Drug: Acthar Gel 80 UNT/ML Injectable Solution

First Posted Date: 2022-09-19

Last Posted Date: 2022-10-31

Lead Sponsor: NephroNet, Inc.

Target Recruit Count: 34

Registration Number: NCT05546047

Locations: 🇺🇸
Stanford University, Stanford, California, United States
🇺🇸
Northeast Clinical Research Center, Bethlehem, Pennsylvania, United States
🇺🇸
Georgia Nephrology DBA Georgia Nephrology Research Institute, Lawrenceville, Georgia, United States

and more 2 locations

Ketogenic Diet vs ACTH for the Treatment of Children With West Syndrome

Phase 2

Active, not recruiting

Conditions: Ketogenic Diet
West Syndrome
Infantile Spasm
ACTH

Interventions: Dietary Supplement: Ketogenic diet
Drug: ACTH

First Posted Date: 2022-03-15

Last Posted Date: 2024-06-25

Lead Sponsor: All India Institute of Medical Sciences, New Delhi

Target Recruit Count: 80

Registration Number: NCT05279118

Locations: 🇮🇳
All India Institute of Medical Sciences, New Delhi, Delhi, India
🇮🇳
AIIMS, New Delhi, India

Perio. Maint. With Diode LBR

Phase 1

Completed

Conditions: Chronic Periodontitis

Interventions: Device: Sham
Drug: HP
Device: Epic Diode

First Posted Date: 2022-03-11

Last Posted Date: 2023-05-03

Lead Sponsor: Biolase Inc

Target Recruit Count: 14

Registration Number: NCT05276817

Locations: 🇺🇸
Stephen John, DDS, San Mateo, California, United States

Treatment of Refractory Gout With ACTH or Methylprednisolone

Not Applicable

Conditions: Gout

Interventions: Drug: Methylprednisolone Injection
Drug: Adrenocorticotropic Hormone

First Posted Date: 2021-03-22

Last Posted Date: 2021-03-22

Lead Sponsor: Shanghai 10th People's Hospital

Target Recruit Count: 60

Registration Number: NCT04808856

Locations: 🇨🇳
Shanghai Tenth People's hospital, Shanghai, Shanghai, China

Corticotropin Stimulation in Adrenal Venous Sampling for Patients With Primary Aldosteronism(ADOPA)

Not Applicable

Completed

Conditions: Primary Aldosteronism

Interventions: Drug: Adrenocorticotropic hormone

First Posted Date: 2020-07-08

Last Posted Date: 2023-12-29

Lead Sponsor: Chongqing Medical University

Target Recruit Count: 228

Registration Number: NCT04461535

Locations: 🇨🇳
The First Affilated Hospital of Chongqing Medical University, Chongqing, Chongqing, China

ACTH vs Betamethasone in Hospitalized Patients With Acute Gout

Not Applicable

Conditions: Gout Attack

Interventions: Drug: ACTH
Drug: Betamethasone

First Posted Date: 2020-03-13

Last Posted Date: 2020-03-13

Lead Sponsor: University of Patras

Target Recruit Count: 60

Registration Number: NCT04306653

Locations: 🇬🇷
University Hospital of Patras, PAtras, Achaia, Greece

Impact of Acthar on Everyday Life of Participants With Severe Keratitis

Phase 4

Completed

Conditions: Keratitis

Interventions: Drug: Acthar

First Posted Date: 2019-11-19

Last Posted Date: 2021-08-18

Lead Sponsor: Mallinckrodt

Target Recruit Count: 36

Registration Number: NCT04169061

Locations: 🇺🇸
Cornea and Cataract Consultants of Arizona, Phoenix, Arizona, United States
🇺🇸
Global Research Management, Inc., Glendale, California, United States
🇺🇸
Eye Research Foundation, Newport Beach, California, United States

and more 6 locations