Corticotropin

Generic Name
Corticotropin
Brand Names
Acthar, Cortrophin
Drug Type
Biotech
Chemical Formula
-
CAS Number
12427-33-7
Unique Ingredient Identifier
K0U68Q2TXA
Background

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

Indication

For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.

Purified corticotropin for injection is indicated for a variety of allergic and autoimmune conditions.

Associated Conditions
Acute Gouty Arthritis, Allergic Conjunctivitis (AC), Ankylosing Spondylitis (AS), Atopic Dermatitis, Chorioretinitis, Choroiditis, Infantile Spasms (IS), Iridocyclitis, Iritis, Keratitis, Multiple sclerosis exacerbation, Optic Neuritis, Polymyositis, Psoriatic Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Serum Sickness, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Anterior eye segment inflammation, Severe Erythema multiforme, Severe Psoriasis, Symptomatic Sarcoidosis, Systemic Dermatomyositis
Associated Therapies
-

Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) Methylprednisolone

First Posted Date
2009-07-28
Last Posted Date
2016-03-22
Lead Sponsor
Neurologique Foundation, Inc.
Target Recruit Count
30
Registration Number
NCT00947895
Locations
🇺🇸

Neurologique Foundation, Inc., Ponte Vedra, Florida, United States

Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis

Phase 4
Terminated
Conditions
Interventions
First Posted Date
2009-03-03
Last Posted Date
2013-04-22
Lead Sponsor
Elliot Frohman
Target Recruit Count
1
Registration Number
NCT00854750
Locations
🇺🇸

UT Southwestern Medical Center, Dallas, Texas, United States

Dose-Finding Pilot Study of ACTH in Patients With Idiopathic Membranous Nephropathy

Phase 1
Completed
Conditions
Interventions
First Posted Date
2008-12-10
Last Posted Date
2014-10-13
Lead Sponsor
Mayo Clinic
Target Recruit Count
20
Registration Number
NCT00805753
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇨🇦

University of Toronto, Toronto, Ontario, Canada

Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock

Not Applicable
Completed
Conditions
First Posted Date
2000-06-05
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Target Recruit Count
56
Registration Number
NCT00005890
Locations
🇺🇸

Children's Hospital Medical Center - Cincinnati, Cincinnati, Ohio, United States

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