Corticotropin

Generic Name
Corticotropin
Brand Names
Acthar, Cortrophin
Drug Type
Biotech
Chemical Formula
-
CAS Number
12427-33-7
Unique Ingredient Identifier
K0U68Q2TXA
Background

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

Indication

For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.

Purified corticotropin for injection is indicated for a variety of allergic and autoimmune conditions.

Associated Conditions
Acute Gouty Arthritis, Allergic Conjunctivitis (AC), Ankylosing Spondylitis (AS), Atopic Dermatitis, Chorioretinitis, Choroiditis, Infantile Spasms (IS), Iridocyclitis, Iritis, Keratitis, Multiple sclerosis exacerbation, Optic Neuritis, Polymyositis, Psoriatic Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Serum Sickness, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Anterior eye segment inflammation, Severe Erythema multiforme, Severe Psoriasis, Symptomatic Sarcoidosis, Systemic Dermatomyositis
Associated Therapies
-
Clinical Trials
Related News

Acthar for Treatment of Post-transplant FSGS

First Posted Date
2015-03-26
Last Posted Date
2021-08-30
Lead Sponsor
University of North Carolina, Chapel Hill
Registration Number
NCT02399462
Locations
🇺🇸

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

ACTH for Fatigue in Multiple Sclerosis Patients

First Posted Date
2014-12-12
Last Posted Date
2019-09-09
Lead Sponsor
Providence Health & Services
Target Recruit Count
8
Registration Number
NCT02315872
Locations
🇺🇸

North Central Neurology Associates, PC, Cullman, Alabama, United States

🇺🇸

Providence Medical Group - Medford Neurology, Medford, Oregon, United States

🇺🇸

Swedish Medical Center, Seattle, Washington, United States

and more 2 locations

CNS Sarcoidosis and Acthar Gel

Phase 4
Completed
Conditions
CNS Sarcoidosis
Interventions
Drug: H.P. Acthar Gel
First Posted Date
2014-11-24
Last Posted Date
2021-04-09
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
4
Registration Number
NCT02298491
Locations
🇺🇸

University of Maryland, Baltimore, Baltimore, Maryland, United States

Effects of Acthar on Recovery From Cognitive Relapses in MS

Phase 3
Completed
Conditions
Multiple Sclerosis
Interventions
Drug: Adrenocorticotropic Hormone
First Posted Date
2014-11-14
Last Posted Date
2020-04-06
Lead Sponsor
State University of New York at Buffalo
Target Recruit Count
64
Registration Number
NCT02290444
Locations
🇺🇸

University at Buffalo-State University of New York, Department of Neurology, Buffalo General Hospital, Buffalo, New York, United States

Tolerability of Acthar for the Treatment of Multiple Sclerosis in Relapses (TAMS)

Not Applicable
Completed
Conditions
Relapsing Remitting Multiple Sclerosis
Interventions
Drug: Acthar
First Posted Date
2014-10-07
Last Posted Date
2020-09-01
Lead Sponsor
OhioHealth
Target Recruit Count
30
Registration Number
NCT02258217
Locations
🇺🇸

OhioHealth, Columbus, Ohio, United States

Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis

First Posted Date
2014-09-22
Last Posted Date
2024-06-11
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
19
Registration Number
NCT02245841
Locations
🇺🇸

Cleveland Clinic, Cleveland, Ohio, United States

Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome

Phase 3
Completed
Conditions
Nephrotic Syndrome
Interventions
Drug: ACTH
First Posted Date
2014-05-07
Last Posted Date
2019-05-29
Lead Sponsor
Emory University
Target Recruit Count
31
Registration Number
NCT02132195
Locations
🇺🇸

Pediatric Nephrology of Alabama, PC., Birmingham, Alabama, United States

🇺🇸

Nemours Children's Hospital, Orlando, Florida, United States

🇺🇸

Riley Hospital for Children, Indianapolis, Indiana, United States

and more 13 locations

Evaluation of Neuroinflammation in Children With Infantile Spasms

Phase 4
Completed
Conditions
Infantile Spasms
Interventions
Drug: ACTH
First Posted Date
2014-03-20
Last Posted Date
2017-11-07
Lead Sponsor
Wayne State University
Target Recruit Count
8
Registration Number
NCT02092883
Locations
🇺🇸

Children's Hospital of Michigan, Detroit, Michigan, United States

Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients

Phase 4
Terminated
Conditions
Proteinuria
Transplant Glomerulopathy
Interventions
Drug: Acthar
First Posted Date
2014-02-07
Last Posted Date
2020-09-04
Lead Sponsor
University of Illinois at Chicago
Target Recruit Count
2
Registration Number
NCT02057523
Locations
🇺🇸

University of Illinois at Chicago, Chicago, Illinois, United States

ACTH Treatment of APOL1- Associated Nephropathy

Not Applicable
Withdrawn
Conditions
Kidney Disease
Interventions
Drug: Acthar
First Posted Date
2013-12-10
Last Posted Date
2017-11-07
Lead Sponsor
Wake Forest University Health Sciences
Registration Number
NCT02006849
Locations
🇺🇸

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States

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