Naphazoline
- Generic Name
- Naphazoline
- Brand Names
- Advanced Eye Relief Redness Instant Relief, Ak-con, Clear Eyes Complete, Clear Eyes Cooling Comfort, Clear Eyes Redness Relief Reformulated Nov 2011, Naphcon, Naphcon A, Opcon-A, Privine, Vasocon, Visine-A
- Drug Type
- Small Molecule
- Chemical Formula
- C14H14N2
- CAS Number
- 835-31-4
- Unique Ingredient Identifier
- H231GF11BV
- Background
Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations.
Naphazoline was first developed in 1942 as a nasal formulation for congestion.
- Indication
Naphazoline is indicated for use as OTC eyedrops for ocular vasoconstriction or as a nasal preparation for nasal congestion.
- Associated Conditions
- Allergic Conjunctivitis (AC), Bacterial Conjunctivitis, Blepharoconjunctivitis, Conjunctivitis, Dacryocystitis, Dacryostenosis, Dermatitis, Eczematous of the Eyelid, Eye Pain, Eye redness, Foreign body sensation in eyes, Iritis, Lacrimation, Nasal Allergies, Nasal Congestion, Noninfective conjunctivitis, Otitis Media (OM), Photophobia, Ocular bacterial infections
- Associated Therapies
- Ocular vasoconstriction therapy
Evaluation of SAR408701 in Japanese Patients With Advanced Malignant Solid Tumors
- Conditions
- Interventions
- First Posted Date
- 2017-10-27
- Last Posted Date
- 2023-01-09
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 34
- Registration Number
- NCT03324113
- Locations
- 🇯🇵
Investigational Site Number 3920002, Nagoya-Shi, Japan
🇯🇵Investigational Site Number 3920003, Kashiwa-Shi, Japan
🇯🇵Investigational Site Number 3920001, Sunto-Gun, Japan
Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Acute Allergic Conjunctivitis.
- Conditions
- Interventions
- First Posted Date
- 2008-10-09
- Last Posted Date
- 2020-10-27
- Lead Sponsor
- Bausch & Lomb Incorporated
- Target Recruit Count
- 141
- Registration Number
- NCT00770133
- Locations
- 🇺🇸
Ophthalmic Research Consultants, Inc., North Andover, Massachusetts, United States
Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Allergic Conjunctivitis.
- Conditions
- Interventions
- First Posted Date
- 2008-10-09
- Last Posted Date
- 2024-04-03
- Lead Sponsor
- Bausch & Lomb Incorporated
- Target Recruit Count
- 144
- Registration Number
- NCT00769886
- Locations
- 🇺🇸
Ophthalmic Research Consultants, Inc., North Andover, Massachusetts, United States
Drug Development Updates
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