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Naphazoline

Generic Name
Naphazoline
Brand Names
Advanced Eye Relief Redness Instant Relief, Ak-con, Clear Eyes Complete, Clear Eyes Cooling Comfort, Clear Eyes Redness Relief Reformulated Nov 2011, Naphcon, Naphcon A, Opcon-A, Privine, Vasocon, Visine-A
Drug Type
Small Molecule
Chemical Formula
C14H14N2
CAS Number
835-31-4
Unique Ingredient Identifier
H231GF11BV

Overview

Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations. Naphazoline was first developed in 1942 as a nasal formulation for congestion.

Background

Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations. Naphazoline was first developed in 1942 as a nasal formulation for congestion.

Indication

Naphazoline is indicated for use as OTC eyedrops for ocular vasoconstriction or as a nasal preparation for nasal congestion.

Associated Conditions

  • Allergic Conjunctivitis (AC)
  • Bacterial Conjunctivitis
  • Blepharoconjunctivitis
  • Conjunctivitis
  • Dacryocystitis
  • Dacryostenosis
  • Dermatitis, Eczematous of the Eyelid
  • Eye Pain
  • Eye redness
  • Foreign body sensation in eyes
  • Iritis
  • Lacrimation
  • Nasal Allergies
  • Nasal Congestion
  • Noninfective conjunctivitis
  • Otitis Media (OM)
  • Photophobia
  • Ocular bacterial infections

FDA Approved Products

AK-Con
Manufacturer:Rebel Distributors Corp.
Route:OPHTHALMIC
Strength:1 mg in 1 mL
Approved: 2006/05/30
NDC:21695-915
Exchange Select Maximum Redness Relief Eye Drops
Manufacturer:Army and Air Force Exchange Service
Route:OPHTHALMIC
Strength:0.03 g in 100 mL
Approved: 2024/01/01
NDC:55301-998
Harris Teeter Redness Relief Eye Drops
Manufacturer:Harris Teeter, LLC.
Route:OPHTHALMIC
Strength:0.012 g in 100 mL
Approved: 2024/01/01
NDC:69256-979
Droptics Performance Eye Drops
Manufacturer:Droptics LLC
Route:OPHTHALMIC
Strength:0.03 g in 100 mL
Approved: 2025/03/24
NDC:85211-001
DERMFREE ORIGINAL NASAL
Manufacturer:Jiangxi Yudexi Pharmaceutical Co., LTD
Route:NASAL
Strength:0.05 g in 100 mL
Approved: 2025/05/02
NDC:85248-006

Singapore Approved Products

FLUCUR NEBULISER
Manufacturer:SHIGAKEN PHARM IND CO LTD
Form:SPRAY
Strength:0.5 mg/ml
Online:Yes
Approved: 1993/02/26
Approval:SIN07343P
NAZAL SPRAY
Manufacturer:SATO PHARMACEUTICAL CO LTD
Form:SPRAY
Strength:50 mg/100 ml
Online:Yes
Approved: 1989/11/06
Approval:SIN03722P
NAPHCON-A STERILE OPHTHALMIC SOLUTION
Manufacturer:ALCON-COUVREUR NV, ALCON SINGAPORE MANUFACTURING PTE. LTD.
Form:SOLUTION
Strength:0.25 mg/ml
Online:Yes
Approved: 1990/06/13
Approval:SIN04717P

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