Overview
Alginic acid, also referred to as algin or alginate, is a hydrophilic or anionic polysaccharide isolated from certain brown seaweed (Phacophycae) via alkaline extraction. It is present in cell walls of brown algae where it forms a viscous gel when binding with water. Alginic acid is a linear polymer consisted of L-glucuronic acid and D-mannuronic acid residues connected via 1,4-glycosidic linkages . Available in different types of salt, alginic acid has been used in a variety of uses in food, cosmetics and pharmaceu-tical products for over 100 years . Alginic acid is an FDA-approved food ingredient in soup and soup mixes as an emulsifier, thickener, and stabilizer . It is also available in oral dietary supplements and is found in antacids such as Gaviscon to inhibit gastroesophageal reflux by creating a physical barrier in presence of gastric acid . Alginate-based raft-forming formulations in the management of heartburn and gastric acid reflux have been used worldwide for over 30 years .
Indication
Indicated for the management of gastric reflux, reflux oesophagitis, hiatus hernia, heartburn (including heartburn of pregnancy) and similar gastric distress .
Associated Conditions
- Dyspepsia
- Flatulence
- Gastro-esophageal Reflux Disease (GERD)
- Gastroesophageal Reflux
- Heartburn
- Reflux Acid
- Reflux Esophagitis (RE)
- Regurgitation
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2022/11/29 | Phase 4 | Active, not recruiting | |||
2019/10/22 | Phase 4 | Completed | |||
2018/08/17 | Phase 4 | Completed | |||
2015/05/27 | Phase 2 | Completed | |||
2014/10/29 | Phase 4 | UNKNOWN | Chang Gung Memorial Hospital | ||
2014/06/06 | Phase 2 | Completed | |||
2013/06/17 | Phase 3 | Completed | |||
2013/06/05 | Phase 3 | Completed | |||
2011/10/12 | Phase 3 | Completed | TTY Biopharm | ||
2011/04/19 | Phase 3 | Completed | Chang Gung Memorial Hospital |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| GAVISCON PEPPERMINT TABLETS | SIN13947P | TABLET, CHEWABLE | 250MG | 4/14/2011 | |
| GASCOVID LIQUID | SIN16041P | SUSPENSION | 500 mg/10ml | 11/17/2020 | |
| GAVISCON ADVANCE-PEPPERMINT FLAVOUR SUSPENSION | SIN12635P | SUSPENSION | 1000 mg/10 ml | 12/24/2004 | |
| GAVISCON LIQUID SACHETS | SIN13738P | SUSPENSION | 500MG/10ML | 11/23/2009 | |
| GAVISCON DOUBLE ACTION LIQUID, SUSPENSION | SIN14016P | SUSPENSION | 500MG/10ML | 9/19/2011 | |
| GASCOVID ADVANCE LIQUID | SIN16042P | SUSPENSION | 1000 MG/10ML | 11/17/2020 | |
| GAVISCON LIQUID | SIN09494P | SUSPENSION | 500 mg/10 ml | 9/13/1997 | |
| GAVISCON DOUBLE ACTION TABLETS | SIN14194P | TABLET, CHEWABLE | 250MG | 7/17/2012 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| GAVISCON EXTRA STRENGTH peppermint flavour chewable tablet blister pack | 156040 | Medicine | A | 10/21/2008 | |
| GAVISCON DUAL ACTION mixed berry flavour oral liquid bottle | 328032 | Medicine | A | 12/23/2019 | |
| GAVISCON INFANT oral powder sachet | 56093 | Medicine | A | 6/24/1996 | |
| MYLANTA 2GO ANTACID DUAL ACTION tablet blister pack | 14378 | Medicine | A | 9/20/1991 | |
| GAVISCON DUAL ACTION mixed berry chewable tablet blister pack | 327045 | Medicine | A | 12/3/2019 | |
| GAVISCON COOL cool mint flavour oral liquid bottle | 127289 | Medicine | A | 4/26/2006 | |
| GAVISCON EXTRA STRENGTH peppermint flavour chewable tablet bottle | 456108 | Medicine | A | 7/23/2024 | |
| GAVISCON EXTRA STRENGTH aniseed oral liquid bottle | 77810 | Medicine | A | 3/13/2001 | |
| GAVISCON aniseed flavour oral liquid bottle | 15383 | Medicine | A | 9/30/1991 | |
| Copy of GAVISCON DUAL ACTION peppermint flavour oral liquid bottle | 158117 | Medicine | A | 12/19/2008 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| RAFTON LIQUID - FRUIT FLAVOUR | Ferring Inc | 01992473 | Liquid - Oral | 250 MG / 5 ML | 12/31/1995 |
| GAVISCON TABLETS | glaxosmithkline consumer healthcare ulc | 02159783 | Tablet - Oral | 200 MG | 12/31/1996 |
| GAVISCON EXTRA STRENGTH STRAWBERRY FL.TABS | smithkline beecham consumer healthcare, division of smithkline beecham inc. | 02159805 | Tablet - Oral | 400 MG | 8/15/1997 |
| HEARTBURN RELIEF | vita health products inc | 02231418 | Tablet - Oral | 200 MG | 7/17/1997 |
| HERB DIGESTIVE CAP | gahler enterprises ltd. | 00727164 | Capsule - Oral | 25 MG / CAP | 12/31/1991 |
| GAVISCON TABS EXTRA STRENGTH | smithkline beecham consumer healthcare, division of smithkline beecham inc. | 02142635 | Tablet - Oral | 400 MG | 12/31/1996 |
| GAVISCON EXTRA STRENGTH BUTTERSCOTCH FLAVOURED TABLETS | smithkline beecham consumer healthcare, division of smithkline beecham inc. | 02230582 | Tablet - Oral | 400 MG | 7/31/1997 |
| ULTRASTAT | wallace, cameron and company ltd. | 00280704 | Aerosol - Topical | 7 % | 12/31/1973 |
| TUMS DUAL ACTION | glaxosmithkline consumer healthcare ulc | 02248628 | Tablet - Oral | 185 MG | 9/1/2004 |
| GAVISCON LIQUID - FRUIT & MINT FLAVOURS | smithkline beecham consumer healthcare, division of smithkline beecham inc. | 02142643 | Liquid - Oral | 250 MG / 5 ML | 12/31/1996 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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