FN-1501

Generic Name
FN-1501
Brand Names
Cellcept, Myfenax, CellCept, Mycophenolate mofetil Teva, Myclausen
Drug Type
Small Molecule
Chemical Formula
C22H25N9O
CAS Number
1429515-59-2
Unique Ingredient Identifier
6MC966B505
Background

Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as Cyclosporine and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants. It is markete...

Indication

Mycophenolate mofetil is indicated in combination with other immunosuppressants to prevent the rejection of kidney, heart, or liver transplants in adult and pediatric patients ≥3 months old. Mycophenolate mofetil may also be used off-label as a second-line treatment for autoimmune hepatitis that has not responded adequately to first-line therapy. Other off-l...

Associated Conditions
Transplanted Organ Rejection
Associated Therapies
-
Clinical Trials
Related News

Tacrolimus and Mycophenolate Mofetil in Preventing Acute Graft-Versus-Host Disease in Patients With Advanced Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplantation

First Posted Date
2004-11-09
Last Posted Date
2010-05-13
Lead Sponsor
Fred Hutchinson Cancer Center
Registration Number
NCT00096096
Locations
🇺🇸

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed by Unrelated Donor Stem Cell Transplant in Treating Patients With Fanconi Anemia

First Posted Date
2004-10-08
Last Posted Date
2017-02-20
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
2
Registration Number
NCT00093743
Locations
🇺🇸

Riley Hospital for Children, Indianapolis, Indiana, United States

🇺🇸

Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois, United States

🇺🇸

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States

and more 2 locations

Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD)

Phase 3
Terminated
Conditions
Cancer
Interventions
Drug: mycophenolate mofetil
Drug: placebo
First Posted Date
2004-08-05
Last Posted Date
2013-05-03
Lead Sponsor
Martin, Paul
Target Recruit Count
151
Registration Number
NCT00089141
Locations
🇨🇦

Princess Margaret Hospital, Toronto, Ontario, Canada

🇺🇸

University of Chicago Cancer Research Center, Chicago, Illinois, United States

🇺🇸

Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota, United States

and more 13 locations

Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer

Phase 2
Completed
Conditions
Accelerated Phase Chronic Myelogenous Leukemia
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Adult Acute Lymphoblastic Leukemia in Remission
Adult Acute Myeloid Leukemia in Remission
Adult Acute Myeloid Leukemia With Del(5q)
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
Adult Nasal Type Extranodal NK/T-cell Lymphoma
Interventions
Drug: fludarabine phosphate
Radiation: total-body irradiation
Drug: mycophenolate mofetil
Drug: tacrolimus
Other: laboratory biomarker analysis
Procedure: peripheral blood stem cell transplantation
Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation
First Posted Date
2004-08-05
Last Posted Date
2020-01-29
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
150
Registration Number
NCT00089011
Locations
🇺🇸

VA Puget Sound Health Care System, Seattle, Washington, United States

🇺🇸

LDS Hospital, Salt Lake City, Utah, United States

🇺🇸

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States

and more 2 locations

Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma

First Posted Date
2004-07-19
Last Posted Date
2019-12-27
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
63
Registration Number
NCT00003196
Locations
🇺🇸

City of Hope Medical Center, Duarte, California, United States

🇺🇸

Stanford University Hospitals and Clinics, Stanford, California, United States

🇺🇸

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

and more 2 locations

Study of Therapeutic Monitoring of Mycophenolate Mofetil (MMF/CellCept) After Kidney Transplantation

First Posted Date
2004-07-14
Last Posted Date
2016-11-06
Lead Sponsor
Hoffmann-La Roche
Target Recruit Count
720
Registration Number
NCT00087581

Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

First Posted Date
2004-06-11
Last Posted Date
2019-11-27
Lead Sponsor
Alliance for Clinical Trials in Oncology
Registration Number
NCT00085449
Locations
🇺🇸

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

🇺🇸

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston, Massachusetts, United States

🇺🇸

Siteman Cancer Center at Barnes-Jewish Hospital, Saint Louis, Missouri, United States

and more 21 locations

Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer

First Posted Date
2004-06-09
Last Posted Date
2020-01-21
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
21
Registration Number
NCT00006251
Locations
🇺🇸

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

🇮🇹

University of Torino, Torino, Italy

Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma

First Posted Date
2004-04-15
Last Posted Date
2020-02-06
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
40
Registration Number
NCT00003954
Locations
🇺🇸

University of Colorado, Denver, Colorado, United States

🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

and more 1 locations

Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

Not Applicable
Completed
Conditions
Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
Childhood Acute Lymphoblastic Leukemia in Remission
Adult Acute Myeloid Leukemia in Remission
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
Childhood Renal Cell Carcinoma
Chronic Phase Chronic Myelogenous Leukemia
Clear Cell Renal Cell Carcinoma
Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma
Adult Acute Myeloid Leukemia With Del(5q)
Interventions
Drug: fludarabine phosphate
Radiation: total-body irradiation
Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Procedure: allogeneic bone marrow transplantation
Procedure: peripheral blood stem cell transplantation
Biological: therapeutic allogeneic lymphocytes
Drug: cyclosporine
Drug: mycophenolate mofetil
Other: pharmacological study
Other: laboratory biomarker analysis
First Posted Date
2004-04-02
Last Posted Date
2019-09-10
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
55
Registration Number
NCT00005799
Locations
🇩🇪

Universitaet Leipzig, Leipzig, Germany

🇺🇸

City of Hope Medical Center, Duarte, California, United States

🇺🇸

Stanford University Hospitals and Clinics, Stanford, California, United States

and more 4 locations
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