Scopolamine
- Generic Name
- Scopolamine
- Brand Names
- Donnatal, Phenohytro, Transderm Scop
- Drug Type
- Small Molecule
- Chemical Formula
- C17H21NO4
- CAS Number
- 51-34-3
- Unique Ingredient Identifier
- DL48G20X8X
- Background
Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine. Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analo...
- Indication
Scopolamine is indicated in adult patients for the prevention of nausea and vomiting associated with motion sickness and for the prevention of postoperative nausea and vomiting (PONV) associated with anesthesia or opiate analgesia.
- Associated Conditions
- Motion Sickness, Post Operative Nausea and Vomiting (PONV)
- Associated Therapies
- Anesthetic premedication therapy
PET and MRI Imaging With Scopolamine at the Muscarinic M1 Receptor
- Conditions
- Interventions
- First Posted Date
- 2023-08-28
- Last Posted Date
- 2024-12-18
- Lead Sponsor
- Yale University
- Target Recruit Count
- 6
- Registration Number
- NCT06014385
- Locations
- 🇺🇸
Yale University, New Haven, Connecticut, United States
Nebulizer Delivery of Intranasal Scopolamine
- First Posted Date
- 2021-08-10
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Dartmouth-Hitchcock Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT04999449
- Locations
- 🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
- Conditions
- Interventions
- First Posted Date
- 2020-04-29
- Last Posted Date
- 2024-07-25
- Lead Sponsor
- Yale University
- Target Recruit Count
- 35
- Registration Number
- NCT04366518
- Locations
- 🇺🇸
Connecticut Mental Health Center, New Haven, Connecticut, United States
Scopolamine in Bipolar Depression
- First Posted Date
- 2019-12-26
- Last Posted Date
- 2024-01-26
- Lead Sponsor
- Dr. Brian Hallahan
- Target Recruit Count
- 50
- Registration Number
- NCT04211961
- Locations
- 🇮🇪
University Hospital Galway, Galway, County Galway, Ireland
Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects
- First Posted Date
- 2019-06-17
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- Repurposed Therapeutics, Inc.
- Target Recruit Count
- 98
- Registration Number
- NCT03988530
- Locations
- 🇺🇸
Collaborative Neuroscience Network, LLC, Long Beach, California, United States
Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels
- First Posted Date
- 2019-04-19
- Last Posted Date
- 2019-04-19
- Lead Sponsor
- Naval Aeromedical Research Unit, Dayton
- Target Recruit Count
- 320
- Registration Number
- NCT03920644
- Locations
- 🇺🇸
NAMRU Dayton, Dayton, Ohio, United States
Scopolamine in Healthy Volunteers
- First Posted Date
- 2019-03-14
- Last Posted Date
- 2020-02-17
- Lead Sponsor
- Repurposed Therapeutics, Inc.
- Target Recruit Count
- 130
- Registration Number
- NCT03874130
- Locations
- 🇺🇸
Collaborative Neuroscience Network, LLC, Long Beach, California, United States
Effectiveness Study of Scopolamine Combined With Escitalopram in Patients With MDD
- Conditions
- Interventions
- First Posted Date
- 2017-04-27
- Last Posted Date
- 2018-12-26
- Lead Sponsor
- Capital Medical University
- Target Recruit Count
- 66
- Registration Number
- NCT03131050
- Locations
- 🇨🇳
Beijing Anding Hospital, Beijing, China
The Effects of Preoperative Scopolamine Patch Application on the Postoperative Nausea and Vomiting in MVD Surgery
- First Posted Date
- 2016-11-18
- Last Posted Date
- 2016-11-18
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02968082
Drug Development Updates
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