Scopolamine

Generic Name
Scopolamine
Brand Names
Donnatal, Phenohytro, Transderm Scop
Drug Type
Small Molecule
Chemical Formula
C17H21NO4
CAS Number
51-34-3
Unique Ingredient Identifier
DL48G20X8X
Background

Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine. Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine analo...

Indication

Scopolamine is indicated in adult patients for the prevention of nausea and vomiting associated with motion sickness and for the prevention of postoperative nausea and vomiting (PONV) associated with anesthesia or opiate analgesia.

Associated Conditions
Motion Sickness, Post Operative Nausea and Vomiting (PONV)
Associated Therapies
Anesthetic premedication therapy
Clinical Trials
Related News

Roflumilast and Donepezil to Reverse Scopolamine Induced Cognitive Deficits in Healthy Adults

First Posted Date
2014-01-31
Last Posted Date
2017-02-01
Lead Sponsor
AstraZeneca
Target Recruit Count
27
Registration Number
NCT02051335

Generalization of Extinction Learning

First Posted Date
2013-07-16
Last Posted Date
2019-10-07
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
60
Registration Number
NCT01900301
Locations
🇺🇸

University of California, Los Angeles, Los Angeles, California, United States

Effect of Hyoscine and Promethazine on Labor Pain

Phase 2
Completed
Conditions
Labor Pain
Interventions
Drug: Promethazine
Drug: Hyoscine
First Posted Date
2012-07-19
Last Posted Date
2012-07-20
Lead Sponsor
Mashhad University of Medical Sciences
Target Recruit Count
93
Registration Number
NCT01644838

Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive Disorder

Not Applicable
Withdrawn
Conditions
Major Depressive Disorder
Interventions
Drug: Ketamine
Drug: Scopolamine
First Posted Date
2012-06-07
Last Posted Date
2018-02-19
Lead Sponsor
Massachusetts General Hospital
Registration Number
NCT01613820
Locations
🇺🇸

Depression Clinical and Reseach Program - MGH, Boston, Massachusetts, United States

Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI

Not Applicable
Completed
Conditions
Cholinergic Function
Interventions
Drug: Scopolamine
Drug: Placebo
Drug: Donepezil
First Posted Date
2011-06-23
Last Posted Date
2013-01-04
Lead Sponsor
Hebrew SeniorLife
Target Recruit Count
60
Registration Number
NCT01379001

A Study of the Use of IV Scopolamine to Augment the Efficacy of Electroconvulsive Therapy (ECT)

Phase 2
Terminated
Conditions
Depression
Interventions
Drug: Scopolamine
First Posted Date
2011-03-11
Last Posted Date
2017-05-30
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
7
Registration Number
NCT01312844
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

Scopolamine Challenge Study

First Posted Date
2010-10-04
Last Posted Date
2018-11-14
Lead Sponsor
Pfizer
Target Recruit Count
38
Registration Number
NCT01213355
Locations
🇫🇷

Pfizer Investigational Site, Rennes, France

A Double-blind Comparison of Scopolamine With Cinnarizin for Prevention of Simulator Sickness

Not Applicable
Conditions
Simulator Sickness
First Posted Date
2010-09-09
Last Posted Date
2010-09-09
Lead Sponsor
Medical Corps, Israel Defense Force
Target Recruit Count
100
Registration Number
NCT01198106
Locations
🇮🇱

base 30 IAF, Yavne, Israel

Comparison of Aprepitant Versus Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting

Not Applicable
Completed
Conditions
Nausea
Vomiting
Interventions
Drug: Aprepitant
Drug: Scopolamine
First Posted Date
2008-07-16
Last Posted Date
2014-05-20
Lead Sponsor
Drexel University
Target Recruit Count
115
Registration Number
NCT00717054
Locations
🇺🇸

Hahnemann University Hospital, Philadelphia, Pennsylvania, United States

Comparison of Oral Aprepitant and Transdermal Scopolamine for Preventing Postoperative Nausea and Vomiting

Not Applicable
Completed
Conditions
Nausea
Vomiting
Interventions
Drug: Aprepitant
Drug: Scopolamine
First Posted Date
2008-04-16
Last Posted Date
2014-05-15
Lead Sponsor
Drexel University College of Medicine
Target Recruit Count
115
Registration Number
NCT00659737
Locations
🇺🇸

Hahnemann University Hospital, Philadelphia, Pennsylvania, United States

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