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Zuranolone is a neuroactive steroid drug used to treat postpartum depression
Zuranolone is a neuroactive steroid drug used to treat postpartum depression
The mechanism of action of zuranolone in the treatment of PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABA receptors. Unlike benzodiazepines, another class of GABA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABA receptors, composed of 2α2βγ subunits, and extrasynaptic GABA receptors, composed of 2α2βδ subunits.
Zuranolone is indicated for the treatment of postpartum depression (PPD) in adults.
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One entry per invention. Patent families filed in the US, EP, WO and CN offices.
