Melatonin
- Generic Name
- Melatonin
- Brand Names
- Circadin, Slenyto, Melatonin Neurim
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2O2
- CAS Number
- 73-31-4
- Unique Ingredient Identifier
- JL5DK93RCL
- Background
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...
- Indication
Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...
- Associated Conditions
- Insomnia
- Associated Therapies
- -
The Contribution of Melatonin Vs. Placebo in Benzodiazepine Withdrawal in Methadone Maintenance Treatment Patients
- Conditions
- First Posted Date
- 2005-12-02
- Last Posted Date
- 2005-12-02
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT00261183
- Locations
- 🇮🇱
Shaul Schreiber, Tel Aviv, Israel
Melatonin Supplements for Improving Sleep in Individuals With Hypertension
- First Posted Date
- 2005-10-13
- Last Posted Date
- 2017-11-14
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 16
- Registration Number
- NCT00238108
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Melatonin Treatment After Laparoscopic Cholecystectomy
- Conditions
- First Posted Date
- 2005-06-13
- Last Posted Date
- 2014-02-11
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Target Recruit Count
- 200
- Registration Number
- NCT00113906
- Locations
- 🇩🇰
University Hospital of Glostrup, Glostrup, Copenhagen, Denmark
🇩🇰Copenhagen University Hospital, Gentofte, Hellerup, Copenhagen, Denmark
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag
- First Posted Date
- 2004-11-24
- Last Posted Date
- 2024-12-02
- Target Recruit Count
- 57
- Registration Number
- NCT00097474
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Study of Melatonin: Sleep Problems in Alzheimer's Disease
- Conditions
- First Posted Date
- 1999-11-01
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Institute on Aging (NIA)
- Registration Number
- NCT00000171
- Locations
- 🇺🇸
University of California Irvine Institute for Brain Aging and Dementia, Irvine, California, United States
🇺🇸Washington University, St. Louis, Missouri, United States
🇺🇸Johns Hopkins University, Baltimore, Maryland, United States
Drug Development Updates
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