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Tropicamide

Generic Name
Tropicamide
Brand Names
Minims Tropicamide, Mydcombi, Mydriacyl, Paremyd
Drug Type
Small Molecule
Chemical Formula
C17H20N2O2
CAS Number
1508-75-4
Unique Ingredient Identifier
N0A3Z5XTC6

Overview

Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors. Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures. It is also used in combination with hydroxyamphetamine for the same indication. Oral tropicamide has been investigated as a potential drug to relieve sialorrhea in patients with Parkinson's Disease.

Background

Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors. Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures. It is also used in combination with hydroxyamphetamine for the same indication. Oral tropicamide has been investigated as a potential drug to relieve sialorrhea in patients with Parkinson's Disease.

Indication

Tropicamide is indicated to induce mydriasis (dilation of the pupil) for diagnostic procedures and in conditions where short-term pupil dilation is desired, either as monotherapy or in combination with hydroxyamphetamine or phenylephrine. It provides clinically significant mydriasis with partial cycloplegia.

Associated Conditions

No associated conditions information available.

Clinical Trials

Phase 4
Recruiting
Posted: 2023/10/11
Sponsor:
Islamic Hospital, Jo...
Not Applicable
Posted: 2022/10/04
Sponsor:
Mantis Photonics AB
Phase 4
Completed
Posted: 2022/07/05
Sponsor:
Islamic Hospital, Jo...

FDA Approved Products

Mydriacyl
Manufacturer:Alcon Laboratories, Inc.
Route:OPHTHALMIC
Strength:10 mg in 1 mL
Approved: 2019/01/28
NDC:0065-0355
Tropicamide
Manufacturer:Sandoz Inc
Route:OPHTHALMIC
Strength:5 mg in 1 mL
Approved: 2020/10/23
NDC:61314-354
Tropicamide
Manufacturer:Bausch & Lomb Incorporated
Route:OPHTHALMIC
Strength:10 mg in 1 mL
Approved: 2023/09/01
NDC:24208-585
Mydriacyl
Manufacturer:Alcon Laboratories, Inc.
Route:OPHTHALMIC
Strength:10 mg in 1 mL
Approved: 2021/12/13
NDC:0998-0355
Tropicamide
Manufacturer:Bausch & Lomb Incorporated
Route:OPHTHALMIC
Strength:5 mg in 1 mL
Approved: 2023/09/01
NDC:24208-590

Singapore Approved Products

MINIMS TROPICAMIDE EYE DROPS 1% w/v
Manufacturer:LABORATOIRE CHAUVIN SA
Form:SOLUTION
Strength:1% w/v
Online:Yes
Approved: 1990/04/20
Approval:SIN04202P
MYDRIACYL STERILE OPHTHALMIC SOLUTION 1%
Manufacturer:ALCON-COUVREUR NV
Form:SOLUTION
Strength:10.0mg/ml
Online:Yes
Approved: 1990/06/13
Approval:SIN04715P

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