Acetylcysteine

Generic Name
Acetylcysteine
Brand Names
Acetadote
Drug Type
Small Molecule
Chemical Formula
C5H9NO3S
CAS Number
616-91-1
Unique Ingredient Identifier
WYQ7N0BPYC
Background

Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.

Acetylcysteine was granted FDA approval on 14 September 1963.

Indication

Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.

Associated Conditions
Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
Associated Therapies
Airway secretion clearance therapy
psychologytoday.com
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Cannabis Use Disorders in Teens and Adults

Cannabis use disorder (CUD) affects 14.2 million Americans, with 9% of users developing CUD, rising to 17% for adolescent starters and 30% for daily users. Adolescent drug use dropped in 2024, but high-potency cannabis products increase CUD risk. CUD symptoms include impaired control, social impairment, risky use, and pharmacological criteria. Emergency visits for cannabis-related issues are rising, particularly among 15-24 year-olds. Cannabinoid hyperemesis syndrome (CHS) causes severe nausea and vomiting, with cessation of cannabis use the only cure. No FDA-approved treatments exist for CUD, but clinical trials explore potential treatments like CBD, FAAH inhibitors, and N-acetylcysteine (NAC). Parental cannabis use influences teens' attitudes and intentions to use, highlighting the need for open conversations and clear boundaries.
nashvillepost.com
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Cumberland Pharmaceuticals stock pops | Area Stocks

Cumberland Pharmaceuticals' stock surged 96.77% after FDA approval of a simplified dosing regimen for Acetadote, an intravenous drug preventing liver injury from acetaminophen overdose. The new regimen aims to improve patient outcomes and reduce healthcare provider burden.
gurufocus.com
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Cumberland Stock Soars 90% After FDA Approval for Acetadote Dosing Change

Cumberland Pharmaceuticals' stock surged over 90% today, up 101% in a month, driven by FDA approval of a supplementary New Drug Application for Acetadote®, simplifying dose schedules to improve safety and efficacy in treating liver damage from acetaminophen. Hospitals have adopted the strategy to reduce medication errors and severe non-allergic anaphylactoid responses. The FDA's Orphan Drug and Rare Pediatric Disease Designations for its Duchenne muscular dystrophy medication have also boosted investor confidence.
pharmacytimes.com
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IV Form of NAC Receives FDA sNDA to Prevent, Lessen Liver Injury After Ingesting Toxic

The FDA approved a simplified dosing regimen for N-acetylcysteine (NAC) to prevent liver injury from acetaminophen overdose, reducing medication errors and non-allergic anaphylactoid reactions (NAARs). Studies show the 2-bag regimen shortens delays and reduces NAARs compared to the 3-bag regimen, improving patient outcomes.
contractpharma.com
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FDA Approves Simplified Dosing For Cumberland's Acetadote

The FDA approved a simplified dosing regimen for Cumberland Pharmaceuticals Inc.'s Acetadote, aiming to prevent liver injury from acetaminophen poisoning by combining the first two bags of the standard regimen into a single, slower infusion to reduce medication errors and non-allergic anaphylactoid reactions.
stocktitan.net
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FDA APPROVES ACETADOTE® sNDA

Cumberland Pharmaceuticals announces FDA approval for a simplified dosing regimen of Acetadote, aiming to reduce medication errors and improve patient outcomes in treating acetaminophen poisoning.
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