Acetylcysteine
- Generic Name
- Acetylcysteine
- Brand Names
- Acetadote
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3S
- CAS Number
- 616-91-1
- Unique Ingredient Identifier
- WYQ7N0BPYC
- Background
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.
Acetylcysteine was granted FDA approval on 14 September 1963.
- Indication
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
- Associated Conditions
- Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
- Associated Therapies
- Airway secretion clearance therapy
COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
- Conditions
- Interventions
- First Posted Date
- 2007-07-06
- Last Posted Date
- 2014-01-14
- Lead Sponsor
- National University Hospital, Singapore
- Target Recruit Count
- 477
- Registration Number
- NCT00497328
- Locations
- 🇸🇬
The Heart Institute, Singapore, Singapore
Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Contrast-Induced Nephropathy
- Conditions
- First Posted Date
- 2007-06-27
- Last Posted Date
- 2007-06-27
- Lead Sponsor
- Technical University of Munich
- Target Recruit Count
- 254
- Registration Number
- NCT00492518
- Locations
- 🇩🇪
Klinikum Rechts der Isar; Technical University of Munich, Munich, Germany
Homocystinuria: Treatment With N-Acetylcysteine
- First Posted Date
- 2007-06-07
- Last Posted Date
- 2009-02-18
- Lead Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Target Recruit Count
- 5
- Registration Number
- NCT00483314
- Locations
- 🇨🇦
Royal Victoria Hospital, Montreal, Quebec, Canada
🇨🇦MUHC-Royal Victoria Hospital, Montreal, Quebec, Canada
Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome
- First Posted Date
- 2007-05-01
- Last Posted Date
- 2013-08-02
- Lead Sponsor
- National Human Genome Research Institute (NHGRI)
- Target Recruit Count
- 3
- Registration Number
- NCT00467831
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Hyperbaric Oxygen, Oxidative Stress, NO Bioavailability and Tissue Oxygenation
- Conditions
- First Posted Date
- 2007-04-20
- Last Posted Date
- 2008-10-17
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT00463671
- Locations
- 🇮🇱
The Institute of Hyperbaric Medicine and Wound Care Clinic, Zerifin, Israel
A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders
- Conditions
- Interventions
- First Posted Date
- 2007-03-28
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- Indiana University School of Medicine
- Target Recruit Count
- 31
- Registration Number
- NCT00453180
- Locations
- 🇺🇸
Riley Hospital, Riley Child and Adolescent Psychiatry Clinic, Indianapolis, Indiana, United States
Improved Estimation of GFR by Cystatin C in Preventing Contrast Induced Nephropathy by NAC or Zn
- Conditions
- First Posted Date
- 2006-11-14
- Last Posted Date
- 2007-02-01
- Target Recruit Count
- 60
- Registration Number
- NCT00399256
- Locations
- 🇩🇪
Robert-Bosch-Hospital, Stuttgart, Germany
Role of Acetylcysteine in Creatinine Clearance
- Conditions
- First Posted Date
- 2006-11-06
- Last Posted Date
- 2006-11-06
- Lead Sponsor
- Eastern Virginia Medical School
- Target Recruit Count
- 35
- Registration Number
- NCT00396396
- Locations
- 🇺🇸
Eastern Virginia Medical School/Nephrology Associates, Norfolk, Virginia, United States
Study of N-Acetylcysteine (NAC) and Continuous Renal Replacement Therapy (CRRT) for the Treatment of Rhabdomyolysis
- Conditions
- Interventions
- First Posted Date
- 2006-10-25
- Last Posted Date
- 2012-03-05
- Lead Sponsor
- Royal Alexandra Hospital
- Target Recruit Count
- 3
- Registration Number
- NCT00391911
- Locations
- 🇨🇦
Royal Alexandra Hospital, Edmonton, Alberta, Canada
🇸🇦King Fahad National Guard Hospital, Riyadh, Saudi Arabia
N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)
- Conditions
- Interventions
- First Posted Date
- 2006-09-08
- Last Posted Date
- 2012-01-19
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 21
- Registration Number
- NCT00374088
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Drug Development Updates
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