Sitagliptin

Generic Name
Sitagliptin
Brand Names
Janumet, Januvia, Ristaben, Steglujan, Tesavel, Velmetia, Xelevia, Sitagliptin SUN, Sitagliptin Accord
Drug Type
Small Molecule
Chemical Formula
C16H15F6N5O
CAS Number
486460-32-6
Unique Ingredient Identifier
QFP0P1DV7Z
Background

Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar. Sitagliptin was granted FDA approval on Oct...

Indication

Sitagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is not used to treat type 1 diabetes or patients with a history of pancreatitis.

It is also used in combination with metformin or ertugliflozin.

Associated Conditions
Type 2 Diabetes Mellitus
Associated Therapies
-

The Effect of Glimepiride Compared With Sitagliptin as an add-on Therapy to Metformin in Severe Insulin Deficiency Diabetes

First Posted Date
2022-05-23
Last Posted Date
2022-05-23
Lead Sponsor
Peking University People's Hospital
Target Recruit Count
192
Registration Number
NCT05386186
Locations
🇨🇳

Peking University People's Hospital, Beijing, Please Select, China

The Combination of Sitagliptin and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

First Posted Date
2022-04-29
Last Posted Date
2022-04-29
Lead Sponsor
Peking University People's Hospital
Target Recruit Count
120
Registration Number
NCT05353673
Locations
🇨🇳

Peking University Insititute of Hematology, Peking University People's Hospital, Beijing, Beijing, China

Cognitive Protective Effect of Newer Antidiabetic Drugs

First Posted Date
2022-04-26
Last Posted Date
2022-07-26
Lead Sponsor
Alexandria University
Target Recruit Count
100
Registration Number
NCT05347459
Locations
🇪🇬

Alexandria University, Alexandria, Egypt

Phase 1 Bioequivalence Study of Dapagliflozin/Sitagliptin FDC vs Loose Combination of Single Components

First Posted Date
2022-03-04
Last Posted Date
2022-07-05
Lead Sponsor
AstraZeneca
Target Recruit Count
46
Registration Number
NCT05266404
Locations
🇩🇪

Research Site, Berlin, Germany

Effects of Sitagliptin in Relatives of T1D Patients

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2022-02-02
Last Posted Date
2023-05-10
Lead Sponsor
University of Milan
Target Recruit Count
70
Registration Number
NCT05219409
Locations
🇮🇹

ASST FBF Sacco, Milan, Italy

Replication of the GRADE Diabetes Trial in Healthcare Claims Data

Completed
Conditions
Interventions
First Posted Date
2021-10-29
Last Posted Date
2023-07-27
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
6403
Registration Number
NCT05099198
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Replication of the DAPA-CKD (Chronic Kidney Disease) Trial in Healthcare Claims Data

First Posted Date
2021-05-12
Last Posted Date
2023-07-28
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
87727
Registration Number
NCT04882813
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study

First Posted Date
2020-06-01
Last Posted Date
2024-03-08
Lead Sponsor
Joslin Diabetes Center
Target Recruit Count
21
Registration Number
NCT04409795
Locations
🇺🇸

Joslin Diabetes Center, Boston, Massachusetts, United States

The Effect of Sitagliptin Treatment in COVID-19 Positive Diabetic Patients

First Posted Date
2020-04-28
Last Posted Date
2021-09-28
Lead Sponsor
University of Milan
Target Recruit Count
170
Registration Number
NCT04365517
Locations
🇮🇹

ASST FBF Sacco, Milan, Italy

Effects of SGLT2i on the Cognitive Function in T2DM Patient (ESCDP)

First Posted Date
2020-03-11
Last Posted Date
2024-05-30
Lead Sponsor
Third Military Medical University
Target Recruit Count
100
Registration Number
NCT04304261
Locations
🇨🇳

Zhiming Zhu, Chongqing, Chongqing, China

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