Megestrol acetate
- Generic Name
- Megestrol acetate
- Brand Names
- Megace
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4
- CAS Number
- 595-33-5
- Unique Ingredient Identifier
- TJ2M0FR8ES
- Background
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
- Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
- Associated Conditions
- Anorexia, Cachexia, Inoperable Carcinoma of Breast, Inoperable Endometrial Carcinoma, Metastatic Breast Carcinoma, Recurrent Breast Carcinoma, Recurrent Endometrial Carcinoma, Significant, Unexplained Weight Loss, Metastatic Endometrial carcinoma
- Associated Therapies
- Palliative Treatment
Phase 1 Study of Daewon-ES(B) & Megace in Healthy Male Volunteers Under Fasting and Fed Condition
- First Posted Date
- 2011-10-21
- Last Posted Date
- 2014-06-25
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 56
- Registration Number
- NCT01456624
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
A Clinical Trial to Evaluate Pharmacokinetics of Daewon DW-ES(A) 625mg/5ml, Daewon DW-ES(B) 625mg/5ml and Megace 800mg/20ml in Healthy Male Volunteers Under Fed Condition
- First Posted Date
- 2011-06-28
- Last Posted Date
- 2011-06-28
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 15
- Registration Number
- NCT01383330
Multicenter Follow Up Study Of Subjects Who Participated In An Original Protocol Of Exemestane Vs. Megestrol Acetate In Postmenopausal Women With Metastatic Breast Cancer
- Conditions
- Interventions
- First Posted Date
- 2010-11-09
- Last Posted Date
- 2011-05-06
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 84
- Registration Number
- NCT01237327
- Locations
- 🇨🇳
The 2nd Central Hospital of Tianjin, Tianjin, China
🇨🇳Cancer Hospital, Shanghai, China
🇨🇳The 1st Affiliated Hospital, Xi'an Jiao Tong University, Xi'an, China
Megestrol Acetate in Treating Weight Loss or Anorexia in Young Patients With Malignancies Who Are Undergoing Radiation Therapy and/or Chemotherapy
- Conditions
- Interventions
- First Posted Date
- 2010-09-13
- Last Posted Date
- 2015-11-25
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 1
- Registration Number
- NCT01200602
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer
- Conditions
- Interventions
- First Posted Date
- 2008-08-07
- Last Posted Date
- 2019-07-23
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 73
- Registration Number
- NCT00729586
- Locations
- 🇺🇸
North Shore University Hospital, Manhasset, New York, United States
🇺🇸Memorial Sloan-Kettering Cancer Center, New York, New York, United States
🇺🇸MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore, Maryland, United States
Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetate
- First Posted Date
- 2007-12-17
- Last Posted Date
- 2011-08-29
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 7
- Registration Number
- NCT00575029
- Locations
- 🇺🇸
University of Arkansas For Medical Sciences, Little Rock, Arkansas, United States
Study to Evaluate the Effect of Megestrol Acetate in Severe Chronic Obstructive Pulmonary Disease With Loss of Weight
- Conditions
- Interventions
- First Posted Date
- 2007-07-27
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- Rottapharm Spain
- Target Recruit Count
- 40
- Registration Number
- NCT00507949
- Locations
- 🇪🇸
Neumology Service of the Hospital Universitario Dr. Peset, Valencia, Spain
Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia
- First Posted Date
- 2007-07-19
- Last Posted Date
- 2020-11-03
- Lead Sponsor
- Gynecologic Oncology Group
- Target Recruit Count
- 9
- Registration Number
- NCT00503581
- Locations
- 🇺🇸
Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States
🇺🇸The Hospital of Central Connecticut, New Britain, Connecticut, United States
🇺🇸Rush - Copley Medical Center, Aurora, Illinois, United States
Study to Evaluate the Effect of Megestrol Acetate in Weight Loss in Dementia Patients
- First Posted Date
- 2007-07-18
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- Rottapharm Spain
- Target Recruit Count
- 39
- Registration Number
- NCT00503516
- Locations
- 🇪🇸
Hospital Socio Sanitario del Hospitalet, El Hospitalet, Barcelona, Spain
Management of Atypical Endometrial Hyperplasia and Endometrial Carcinoma Using Megestrol Acetate
- Conditions
- Interventions
- First Posted Date
- 2007-06-07
- Last Posted Date
- 2018-04-04
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 31
- Registration Number
- NCT00483327
- Locations
- 🇺🇸
Bellevue Hospital, New York, New York, United States
🇺🇸NYU Cancer Center, New York, New York, United States
Drug Development Updates
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