MedPath

Proglumide

Generic Name
Proglumide
Drug Type
Small Molecule
Chemical Formula
C18H26N2O4
CAS Number
6620-60-6
Unique Ingredient Identifier
EPL8W5565D
Indication

用于治疗胃溃疡和十二指肠溃疡、胃炎等,对消化性溃疡临床的改善、溃疡愈合有较好的疗效。

Associated Conditions
Gastric Ulcer, Intestinal Inflammation, Intestinal ulcer, Gastrointestinal ulceration

Proglumide With Gemcitabine and Nab-Paclitaxel in PatientsWith Metastatic Pancreatic Ductal Adenocarcinoma

Phase 1
Withdrawn
Conditions
Metastatic Pancreatic Cancer
Interventions
First Posted Date
2023-08-30
Last Posted Date
2023-10-25
Lead Sponsor
Georgetown University
Registration Number
NCT06017323
Locations
🇺🇸

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, United States

Proglumide and Chemotherapy for Metastatic Pancreatic Cancer

Phase 2
Recruiting
Conditions
Metastatic Pancreatic Cancer
Interventions
First Posted Date
2023-04-24
Last Posted Date
2024-05-17
Lead Sponsor
Georgetown University
Target Recruit Count
30
Registration Number
NCT05827055
Locations
🇺🇸

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, United States

Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis

Phase 1
Active, not recruiting
Conditions
Safety Issues
Pain
Pancreas Fibrosis
Interventions
Drug: Placebo
First Posted Date
2022-09-23
Last Posted Date
2024-02-01
Lead Sponsor
Georgetown University
Target Recruit Count
32
Registration Number
NCT05551858
Locations
🇺🇸

Georgetown University, Washington, District of Columbia, United States

Single-dose PK Assessment of Oral Proglumide in Those With Hepatic Impairment

Early Phase 1
Completed
Conditions
Cirrhosis, Liver
Interventions
First Posted Date
2021-03-24
Last Posted Date
2022-03-15
Lead Sponsor
Georgetown University
Target Recruit Count
11
Registration Number
NCT04814602
Locations
🇺🇸

Georgetown University, Washington, District of Columbia, United States

Safety and Tolerability of Oral Proglumide for NASH

Phase 1
Completed
Conditions
Nonalcoholic Steatohepatitis
Interventions
First Posted Date
2019-11-05
Last Posted Date
2022-10-13
Lead Sponsor
Georgetown University
Target Recruit Count
18
Registration Number
NCT04152473
Locations
🇺🇸

Georgetown University, Washington, District of Columbia, United States

🇺🇸

Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States

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