Bromfenac
- Generic Name
- Bromfenac
- Brand Names
- Bromday, Bromsite, Prolensa, Xibrom, Yellox
- Drug Type
- Small Molecule
- Chemical Formula
- C15H12BrNO3
- CAS Number
- 91714-94-2
- Unique Ingredient Identifier
- 864P0921DW
- Background
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.
- Indication
For the treatment of postoperative inflammation in patients who have undergone cataract extraction.
- Associated Conditions
- Eye Pain, Ocular Inflammation
CREATE Protocol Shows Promise in Correcting RK-Induced Corneal Irregularity
• A novel CREATE protocol, combining PTK and topography-guided ablation, significantly reduces corneal irregularity in post-RK patients.
• The study showed a 69% reduction in higher-order aberrations and an 80.2% reduction when factoring in lower-order astigmatism and sphere.
• 50% of eyes treated with the CREATE protocol gained between 1 and 9 lines of vision, with 95% achieving 20/40 or better visual acuity.
• The CREATE protocol demonstrates a reliable and safe method for improving visual outcomes in patients with RK-induced corneal issues.
Drug Development Updates
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