Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Ventilatory Heterogeneity in Participants With Asthma (MK-0476-513)

Phase 1

Completed

Conditions: Asthma

Interventions: Drug: Montelukast
Drug: Prednisone

First Posted Date: 2012-06-18

Last Posted Date: 2017-04-20

Lead Sponsor: Hal C Charles

Target Recruit Count: 34

Registration Number: NCT01621386

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Long Term Safety Trial of z102 and Prednisone in Patients With Moderate to Severe Rheumatoid Arthritis

Phase 2

Terminated

Conditions: Rheumatoid Arthritis

Interventions: Drug: Prednisolone-Dipyridamole
Drug: prednisone

First Posted Date: 2012-06-05

Last Posted Date: 2012-09-11

Lead Sponsor: Zalicus

Target Recruit Count: 18

Registration Number: NCT01612377

Locations: 🇷🇸
Nemanja Damjanov, Belgrade, Serbia

Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100

Phase 3

Completed

Conditions: Pain
Prostate Cancer
Castration Resistant Prostate Cancer
Prostatic Neoplasms

Interventions: Drug: cabozantinib
Drug: prednisone

First Posted Date: 2012-05-24

Last Posted Date: 2018-03-14

Lead Sponsor: Exelixis

Target Recruit Count: 1028

Registration Number: NCT01605227

Finding the Optimum Regimen for Duchenne Muscular Dystrophy

Phase 3

Completed

Conditions: Duchenne Muscular Dystrophy

Interventions: Drug: Prednisone
Drug: Deflazacort

First Posted Date: 2012-05-23

Last Posted Date: 2022-08-12

Lead Sponsor: University of Rochester

Target Recruit Count: 196

Registration Number: NCT01603407

Locations: 🇮🇹
C. Besta Neurological Institute Foundation, Milan, Italy
🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇬🇧
Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom

and more 29 locations

Phase I Cabazitaxel, Mitoxantrone, and Prednisone Metastatic Castration-Resistant Prostate Cancer

Phase 1

Completed

Conditions: Metastatic Castration-resistant Prostate Cancer

Interventions: Drug: Cabazitaxel
Drug: Mitoxantrone
Drug: Prednisone
Drug: Pegfilgrastim

First Posted Date: 2012-05-09

Last Posted Date: 2017-07-21

Lead Sponsor: Rahul Aggarwal

Target Recruit Count: 25

Registration Number: NCT01594918

Locations: 🇺🇸
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
🇺🇸
Mayo Clinic, Scottsdale, Arizona, United States
🇺🇸
UCSF Comprehensive Cancer Center, San Francisco, California, United States

Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.

Phase 2

Conditions: Anemia
Anemia, Hemolytic
Anemia, Hemolytic, Autoimmune
Hemolysis
Hematologic Diseases
Autoimmune Diseases
Immune System Diseases
Pathologic Processes

Interventions: Drug: levamisole
Drug: Prednisone

First Posted Date: 2012-04-17

Last Posted Date: 2012-04-19

Lead Sponsor: Institute of Hematology & Blood Diseases Hospital, China

Target Recruit Count: 100

Registration Number: NCT01579110

Locations: 🇨🇳
Blood Diseases Hospital Chinese Academy of Medical Sciences, TianJin, Tianjin, China

Comparison of Cabazitaxel/Prednisone Alone or in Combination With Custirsen for 2nd Line Chemotherapy in Prostate Cancer

Phase 3

Completed

Conditions: Prostate Cancer

Interventions: Drug: cabazitaxel
Drug: prednisone
Drug: custirsen sodium

First Posted Date: 2012-04-17

Last Posted Date: 2016-10-12

Lead Sponsor: Achieve Life Sciences

Target Recruit Count: 630

Registration Number: NCT01578655

Locations: 🇺🇸
Georgia Cancer Specialists, P.C., Marietta, Georgia, United States
🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
🇨🇿
Krajská nemocnice Liberec a.s., Liberec, Czech Republic

and more 90 locations

Abiraterone Acetate and Prednisone With or Without Veliparib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Phase 2

Completed

Conditions: Recurrent Prostate Carcinoma
Castration-Resistant Prostate Carcinoma
Stage IV Prostate Cancer AJCC v7

Interventions: Drug: Abiraterone Acetate
Other: Laboratory Biomarker Analysis
Drug: Prednisone
Drug: Veliparib

First Posted Date: 2012-04-12

Last Posted Date: 2020-11-12

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 159

Registration Number: NCT01576172

Locations: 🇺🇸
University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States
🇺🇸
City of Hope South Pasadena, South Pasadena, California, United States
🇺🇸
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois, United States

and more 11 locations