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Carboxymethylcellulose

Generic Name
Carboxymethylcellulose
Brand Names
Leader Lubricant Eye Drops, Refresh Drops, Refresh Liquigel, Refresh Optive Advanced, Refresh Optive Extended Therapy, Retaine, Thera Tears, Theratears
Drug Type
Small Molecule
CAS Number
9000-11-7
Unique Ingredient Identifier
05JZI7B19X
Background

Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose monomers and their hydroxyl groups bound to carboxymethyl groups. It is added in food products as a viscosity modifier or thickener and emulsifier. It is also one of the most common viscous polymers used in artificial tears, and has shown to be effective in the treatment of aqueous tear-deficient dry eye symptoms and ocular surface staining . The viscous and mucoadhesive properties as well as its anionic charge allow prolonged retention time in the ocular surface . Sodium carboxymethylcellulose is the most commonly used salt.

Indication

Indicated for the symptomatic relief of burning, irritation and discomfort of the eyes due to dryness or exposure to wind or sun.

Associated Conditions
Dry Eyes, Ocular Irritation

Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITE™) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye

Phase 4
Completed
Conditions
Dry Eye Syndromes
First Posted Date
2006-10-11
Last Posted Date
2015-06-03
Lead Sponsor
Chulalongkorn University
Target Recruit Count
100
Registration Number
NCT00386646
Locations
🇹🇭

Chulalongkorn Hospital, Bangkok, Thailand

Soothe Versus Refresh

Phase 4
Completed
Conditions
Dry Eye Syndromes
First Posted Date
2006-02-01
Last Posted Date
2006-08-22
Lead Sponsor
Pharmaceutical Research Network
Target Recruit Count
33
Registration Number
NCT00284999
Locations
🇺🇸

Coastal Research Associates, LLC, Atlanta, Georgia, United States

🇺🇸

Michigan Cornea Associates, Southfield, Michigan, United States

🇺🇸

Mount Sinai School of Medicine, New York, New York, United States

A Multi-Center Randomized Study to Evaluate the Efficacy and Safety of an Investigational Lubricant Eye Drop

Phase 2
Completed
Conditions
Dry Eye
First Posted Date
2005-10-25
Last Posted Date
2011-05-30
Lead Sponsor
Allergan
Target Recruit Count
286
Registration Number
NCT00243711
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