Aldesleukin
- Generic Name
- Aldesleukin
- Brand Names
- Proleukin
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 110942-02-4
- Unique Ingredient Identifier
- M89N0Q7EQR
- Background
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native in...
- Indication
For treatment of adults with metastatic renal cell carcinoma.
- Associated Conditions
- Metastatic Melanoma, Metastatic Renal Cell Carcinoma ( mRCC)
- Associated Therapies
- -
Interleukin-2 With Sorafenib (BAY 43-9006) for Unresectable or Metastatic Clear Cell Renal Carcinoma (RCC) and Metastatic Melanoma
- First Posted Date
- 2007-01-04
- Last Posted Date
- 2017-02-20
- Target Recruit Count
- 17
- Registration Number
- NCT00418496
- Locations
- 🇺🇸
Ohio State University, Columbus, Ohio, United States
Aldesleukin in Participants With Metastatic Renal Cell Carcinoma or Metastatic Melanoma
- Conditions
- Interventions
- First Posted Date
- 2006-12-22
- Last Posted Date
- 2021-06-08
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 26
- Registration Number
- NCT00414765
- Locations
- 🇺🇸
James Graham Brown Cancer Center, Louisville, Kentucky, United States
🇺🇸USC/Kenneth Norris Comprehensive Cancer Center, Los Angeles, California, United States
🇺🇸University of Colorado Cancer Center, Aurora, Colorado, United States
Trial of Outpatient Immunotherapy With Rituximab and Aldesleukin (IL-2) vs. Rituximab Alone for Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2005-11-08
- Last Posted Date
- 2008-04-21
- Lead Sponsor
- US Oncology Research
- Target Recruit Count
- 110
- Registration Number
- NCT00250861
- Locations
- 🇺🇸
Hematology Oncology Associates of IL, Chicago, Illinois, United States
🇺🇸Pudget Sound Cancer Center-Seattle, Seattle, Washington, United States
🇺🇸Minnesota Oncology Hematology, PA, Minneapolis, Minnesota, United States
Treating Patients With Childhood Acute Myeloid Leukemia With Interleukin-2
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2009-02-12
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 580
- Registration Number
- NCT00149162
- Locations
- 🇫🇷
Children Armand Trousseau Hospital, Paris, France
Safety and Effectiveness of Immunotherapy With Autologous HIV-Specific CD8 Cells in HIV Infected Adults
- Conditions
- First Posted Date
- 2005-05-11
- Last Posted Date
- 2008-08-08
- Target Recruit Count
- 24
- Registration Number
- NCT00110578
- Locations
- 🇺🇸
University of Washington (UW), Seattle, Washington, United States
🇺🇸Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Biological Therapies Following Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Advanced Breast Cancer
- Conditions
- First Posted Date
- 2004-06-21
- Last Posted Date
- 2017-11-29
- Lead Sponsor
- Masonic Cancer Center, University of Minnesota
- Registration Number
- NCT00005993
Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma
- Conditions
- Interventions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2024-10-21
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 1449
- Registration Number
- NCT00026312
- Locations
- 🇺🇸
Rady Children's Hospital - San Diego, San Diego, California, United States
🇺🇸UCSF Medical Center-Parnassus, San Francisco, California, United States
🇺🇸UCSF Medical Center-Mission Bay, San Francisco, California, United States
Interleukin-2 (IL-2) Treatment for HIV Infected Patients Who Have Interrupted Their Anti-HIV Drug Therapy
- Conditions
- First Posted Date
- 2002-05-30
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 21
- Registration Number
- NCT00038259
- Locations
- 🇺🇸
Univ. of Hawaii at Manoa, Leahi Hosp., Honolulu, Hawaii, United States
🇺🇸UCLA CARE Center CRS, Los Angeles, California, United States
🇺🇸UC Davis Medical Center, Sacramento, California, United States
Treatment With Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2012-05-21
- Target Recruit Count
- 110
- Registration Number
- NCT00000923
- Locations
- 🇺🇸
St. Louis ConnectCare, Infectious Diseases Clinic, St Louis, Missouri, United States
🇺🇸Harbor-UCLA Med. Ctr. CRS, Torrance, California, United States
🇺🇸Case CRS, Cleveland, Ohio, United States
A Study of Zidovudine Plus Interleukin-2 in HIV-Infected Patients Who Have No Symptoms of Infection But Who Have Tender Lymph Nodes
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 30
- Registration Number
- NCT00001005
- Locations
- 🇺🇸
Duke Univ. Med. Ctr. Adult CRS, Durham, North Carolina, United States
Drug Development Updates
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