Pegvisomant
- Generic Name
- Pegvisomant
- Brand Names
- Somavert
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 218620-50-9
- Unique Ingredient Identifier
- N824AOU5XV
- Background
Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
- Indication
Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly.
- Associated Conditions
- Acromegaly
- Associated Therapies
- -
Lanreotide Autogel and Pegvisomant Combination Therapy in Acromegalic Patients
- Conditions
- Interventions
- First Posted Date
- 2006-10-03
- Last Posted Date
- 2022-09-27
- Lead Sponsor
- Ipsen
- Target Recruit Count
- 125
- Registration Number
- NCT00383708
- Locations
- 🇩🇪
Charite Campus Mitte, Berlin, Germany
🇫🇷CHU de Rangueil, Toulouse, France
🇮🇹University Federico II, Napoli, Italy
Long Term Study With B2036-PEG
- Conditions
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2008-07-29
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 16
- Registration Number
- NCT00143416
- Locations
- 🇯🇵
Pfizer Investigational Site, Sannomaru-cho, Naka-ku, Nagoya-shi, Japan
A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly
- Conditions
- First Posted Date
- 2003-09-08
- Last Posted Date
- 2008-04-07
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 100
- Registration Number
- NCT00068042
- Locations
- 🇬🇧
Pfizer Investigational Site, London, United Kingdom
Pegvisomant And Sandostatin LAR Combination Study
- Conditions
- First Posted Date
- 2003-09-05
- Last Posted Date
- 2008-04-07
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 75
- Registration Number
- NCT00068029
- Locations
- 🇬🇧
Pfizer Investigational Site, Oxford, United Kingdom
A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome
- Conditions
- First Posted Date
- 2001-06-21
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 10
- Registration Number
- NCT00017927
- Locations
- 🇺🇸
National Institute of Dental And Craniofacial Research (NIDCR), Bethesda, Maryland, United States
Drug Development Updates
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