Nortriptyline

Generic Name
Nortriptyline
Brand Names
Aventyl, Pamelor
Drug Type
Small Molecule
Chemical Formula
C19H21N
CAS Number
72-69-5
Unique Ingredient Identifier
BL03SY4LXB
Background

Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.

Indication

Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD). Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.

Associated Conditions
Chronic Pain, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Myofascial Pain Syndrome, Pain, Orofacial, Postherpetic Neuralgia
Associated Therapies
-
Clinical Trials
Related News

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First Posted Date
2002-09-17
Last Posted Date
2013-08-13
Lead Sponsor
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Target Recruit Count
340
Registration Number
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Locations
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Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States

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New York State Psychiatric Institute at Columbia University, New York, New York, United States

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Wake Forest University, Winston-Salem, North Carolina, United States

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Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

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First Posted Date
2001-07-23
Last Posted Date
2009-09-25
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Target Recruit Count
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Registration Number
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Harbor UCLA Family Health Care Center, Harbor City, California, United States

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UCLA General Outpatient Psychiatry Clinic, Los Angeles, California, United States

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Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation

Phase 2
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Conditions
Smoking
Interventions
Drug: transdermal nicotine
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First Posted Date
2001-07-05
Last Posted Date
2010-09-15
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Target Recruit Count
158
Registration Number
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Locations
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VA Eastern Colorado Health Care System, Denver, Denver, Colorado, United States

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Phase 2
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Conditions
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First Posted Date
2001-02-05
Last Posted Date
2017-07-02
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Registration Number
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Preventing the Return of Depression in Elderly Patients

Not Applicable
Completed
Conditions
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First Posted Date
1999-11-03
Last Posted Date
2013-06-21
Lead Sponsor
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Registration Number
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Antidepressant Treatment of Melancholia in Late Life

Phase 4
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Depression
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Interventions
Drug: Sertraline
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First Posted Date
1999-11-03
Last Posted Date
2015-10-07
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
110
Registration Number
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1051 Riverside Drive, New York, New York, United States

Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia

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