Nortriptyline

Generic Name: Nortriptyline

Brand Names: Aventyl, Pamelor

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₂₁N

CAS Number: 72-69-5

Unique Ingredient Identifier: BL03SY4LXB

Background: Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.

Indication: Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD). Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.

Associated Conditions: Chronic Pain, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Myofascial Pain Syndrome, Pain, Orofacial, Postherpetic Neuralgia

Associated Therapies: -

Clinical Trials

Pediatric Concussion Outcomes

Phase 4

Terminated

Conditions: Headaches Posttraumatic
Concussion Post Syndrome
Mild Traumatic Brain Injury

Interventions: Drug: Placebo
Drug: Nortriptyline

First Posted Date: 2020-01-13

Last Posted Date: 2024-05-29

Lead Sponsor: Lancaster General Hospital

Target Recruit Count: 8

Registration Number: NCT04226365

Locations: 🇺🇸
Penn Medicine Lancaster General Health, Lancaster, Pennsylvania, United States

Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments

Phase 2

Completed

Conditions: Vestibulodynia
Temporomandibular Disorder
Migraines
Tension Headache
Fibromyalgia Syndrome
Interstitial Cystitis
Chronic Fatigue Syndrome
Back Pain
Irritable Bowel Syndrome
Endometriosis

Interventions: Drug: 5% lidocaine/5 mg/ml 0.02% estradiol compound cream
Drug: Nortriptyline
Drug: Placebo pill
Drug: Placebo cream

First Posted Date: 2019-02-18

Last Posted Date: 2024-06-07

Lead Sponsor: Duke University

Target Recruit Count: 223

Registration Number: NCT03844412

Locations: 🇺🇸
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
🇺🇸
University of California, Los Angeles, Los Angeles, California, United States

Nortriptyline for the Treatment of Functional Dyspepsia

Phase 3

Conditions: Functional Dyspepsia

Interventions: Drug: Placebo
Drug: Nortriptyline

First Posted Date: 2018-08-29

Last Posted Date: 2018-09-05

Lead Sponsor: Maastricht University Medical Center

Target Recruit Count: 154

Registration Number: NCT03652571

Locations: 🇳🇱
Medisch Spectrum Twente, Enschede, Netherlands
🇳🇱
Tergooi Hilversum, Hilversum, Netherlands
🇳🇱
Alrijne ziekenhuis, Leiden, Netherlands

and more 11 locations

Antidepressants Trial in Parkinson's Disease

Phase 3

Completed

Conditions: Depression
Parkinson Disease

Interventions: Drug: Placebo
Drug: Nortriptyline
Drug: Escitalopram

First Posted Date: 2018-08-29

Last Posted Date: 2023-05-06

Lead Sponsor: University College, London

Target Recruit Count: 52

Registration Number: NCT03652870

Locations: 🇬🇧
Royal Free London NHS Foundation Trust, London, United Kingdom

Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode

Phase 4

Completed

Conditions: Bipolar Disorder

Interventions: Drug: Lithium Carbonate
Drug: Sertraline
Drug: Nortriptyline
Drug: Risperidone

First Posted Date: 2016-09-28

Last Posted Date: 2020-11-20

Lead Sponsor: Federal University of Rio Grande do Sul

Target Recruit Count: 78

Registration Number: NCT02918097

Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder

Phase 4

Completed

Conditions: Depression

Interventions: Drug: sertraline
Drug: Nortriptyline
Drug: Lithium

First Posted Date: 2016-09-15

Last Posted Date: 2020-10-14

Lead Sponsor: Federal University of Rio Grande do Sul

Target Recruit Count: 68

Registration Number: NCT02901249

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations

Phase 4

Completed

Conditions: Cryptogenic Sensory Polyneuropathy

Interventions: Drug: Nortriptyline
Drug: Mexiletine
Drug: Duloxetine
Drug: Pregabalin

First Posted Date: 2014-10-09

Last Posted Date: 2018-07-06

Lead Sponsor: University of Kansas Medical Center

Target Recruit Count: 402

Registration Number: NCT02260388

Locations: 🇺🇸
Cedars-Sinai Medical Center, Los Angeles, California, United States
🇺🇸
University of Miami Miller School of Medicine, Miami, Florida, United States
🇺🇸
Indiana University, Indianapolis, Indiana, United States

and more 43 locations

Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene

Phase 4

Conditions: Major Depression

Interventions: Drug: Paroxetine
Drug: Sertraline
Drug: Citalopram
Drug: Venlafaxine
Drug: Amitriptyline
Drug: Escitalopram
Drug: Amitriptylinoxide
Drug: Nortriptyline
Drug: Trimipramine

First Posted Date: 2014-09-12

Last Posted Date: 2014-09-12

Lead Sponsor: HolsboerMaschmeyer NeuroChemie GmbH

Target Recruit Count: 80

Registration Number: NCT02237937

Locations: 🇩🇪
Max Planck Institute of Psychiatry, Munich, Bavaria, Germany

Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine

Not Applicable

Terminated

Conditions: Migraine Disorders

Interventions: Behavioral: Diet Modification
Drug: Topiramate
Drug: nortriptyline

First Posted Date: 2014-06-23

Last Posted Date: 2021-04-23

Lead Sponsor: St. Louis University

Target Recruit Count: 35

Registration Number: NCT02169830

Locations: 🇺🇸
Saint Louis University, Saint Louis, Missouri, United States

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