Chloral hydrate
- Generic Name
- Chloral hydrate
- Brand Names
- Nortec
- Drug Type
- Small Molecule
- Chemical Formula
- C2H3Cl3O2
- CAS Number
- 302-17-0
- Unique Ingredient Identifier
- 418M5916WG
- Background
A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
- Indication
Mainly used as a hypnotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
- Associated Conditions
- Alcohol Withdrawal Syndrome, Opioid Withdrawal (Disorder), Postoperative pain, Barbiturate withdrawal
- Associated Therapies
- Sedative therapy
A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI
- Conditions
- Sedation for Children Undergoing MRI
- Interventions
- First Posted Date
- 2024-09-23
- Last Posted Date
- 2025-01-01
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT06606899
- Locations
- 🇪🇬
Ain shams university hospitals, Cairo, Egypt
An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe Insomnia
- First Posted Date
- 2023-09-26
- Last Posted Date
- 2024-11-07
- Lead Sponsor
- Pharmanovia
- Target Recruit Count
- 100
- Registration Number
- NCT06053840
- Locations
- 🇬🇧
Lindus Health, The Leather Market Weston Street, Bermondsey,, London, United Kingdom
Sedation and Nursing Management in EEG Recording in Children
- Conditions
- ElectroencephalographyMelatoninChloral HydrateHydroxyzineSleep Deprivation
- Interventions
- Other: Sedation and Nursing Management in EEG Recording in Children
- First Posted Date
- 2022-08-09
- Last Posted Date
- 2022-08-09
- Lead Sponsor
- Suleyman Demirel University
- Target Recruit Count
- 180
- Registration Number
- NCT05492812
- Locations
- 🇹🇷
Suleyman Demirel University, Isparta, Turkey
Dexmedetomidine in Children Having Transthoracic Echocardiography
- Conditions
- Heart Disease
- Interventions
- First Posted Date
- 2015-08-14
- Last Posted Date
- 2017-07-31
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 279
- Registration Number
- NCT02523144
- Locations
- 🇨🇳
Shanghai Children's Hospital, Shanghai, China
Pharmacovigilance in Gerontopsychiatric Patients
- Conditions
- DementiaDepressionSchizophreniaPsychosomatic DisordersAnxiety Disorders
- Interventions
- First Posted Date
- 2015-03-02
- Last Posted Date
- 2018-02-28
- Lead Sponsor
- Hannover Medical School
- Target Recruit Count
- 407
- Registration Number
- NCT02374567
- Locations
- 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪Hannover Medical School, Hannover, Germany
The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children
- Conditions
- SedationEpilepsyElectroencephalogramChildren
- Interventions
- Dietary Supplement: Melatonin
- First Posted Date
- 2014-07-21
- Last Posted Date
- 2017-11-30
- Lead Sponsor
- University of Cape Town
- Target Recruit Count
- 194
- Registration Number
- NCT02195661
- Locations
- 🇿🇦
Red Cross War Memorial Children's Hospital, Cape Town, Western Cape, South Africa
Evaluation of Pediatric Procedural Sedation With Rectal Chloral Hydrate or Intranasal Midazolam
- Conditions
- Traumatic Brain InjuryComputed TomographyProcedural Sedation
- Interventions
- First Posted Date
- 2011-07-26
- Last Posted Date
- 2013-06-20
- Lead Sponsor
- University of Sao Paulo
- Registration Number
- NCT01402596
- Locations
- 🇧🇷
University of Sao Paulo, Sao Paulo, SP, Brazil
A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams
- Conditions
- Sedation
- Interventions
- First Posted Date
- 2010-12-08
- Last Posted Date
- 2016-05-16
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 90
- Registration Number
- NCT01255904
- Locations
- 🇺🇸
Texas Childrens Hospital, Houston, Texas, United States
Effects of Chloral Hydrate on Induction, Maintenance, and Recovery From Sevoflurane Anesthesia in Day-case Pediatric Surgery
- First Posted Date
- 2010-06-28
- Last Posted Date
- 2011-06-10
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 100
- Registration Number
- NCT01149226
- Locations
- 🇰🇷
Severance Hospital, Seoul, Korea, Republic of
Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate
- Conditions
- Other Conditions of Brain
- Interventions
- First Posted Date
- 2010-03-10
- Last Posted Date
- 2013-10-25
- Lead Sponsor
- Federal University of Minas Gerais
- Target Recruit Count
- 25
- Registration Number
- NCT01083797
- Locations
- 🇧🇷
Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil
Drug Development Updates
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