Trazodone
- Generic Name
- Trazodone
- Brand Names
- Desyrel, Oleptro
- Drug Type
- Small Molecule
- Chemical Formula
- C19H22ClN5O
- CAS Number
- 19794-93-5
- Unique Ingredient Identifier
- YBK48BXK30
- Background
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibito...
- Indication
Trazodone is indicated for the treatment of major depressive disorder (MDD). It has been used off-label for adjunct therapy in alcohol dependence, and off-label to treat anxiety and insomnia. It may also be used off-label to treat symptoms of dementia, Alzheimer’s disease, schizophrenia, eating disorders, and fibromyalgia due to its effects on various neurot...
- Associated Conditions
- Alcohol Dependency, Alzheimer's Disease (AD), Anxiety, Dementia, Eating Disorders Symptoms, Fibromyalgia, Insomnia, Major Depressive Disorder (MDD), Pain, Inflammatory, Schizophrenia, Moderate to severe pain
- Associated Therapies
- -
Quetiapine Versus Trazadone in Women With Postpartum Depression
- Conditions
- Interventions
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Lawson Health Research Institute
- Target Recruit Count
- 50
- Registration Number
- NCT06546358
- Locations
- 🇨🇦
Parkwood Institute, London, Ontario, Canada
Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia
- Conditions
- Interventions
- First Posted Date
- 2024-02-28
- Last Posted Date
- 2024-06-10
- Lead Sponsor
- Milton S. Hershey Medical Center
- Target Recruit Count
- 600
- Registration Number
- NCT06281756
- Locations
- 🇺🇸
National Jewish Health, Denver, Colorado, United States
🇺🇸Penn State University, Hershey, Pennsylvania, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Trazodone vs. Quetiapine for the Treatment of ICU Delirium
- First Posted Date
- 2022-04-01
- Last Posted Date
- 2024-05-08
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 60
- Registration Number
- NCT05307003
- Locations
- 🇺🇸
Keck Hospital of the University of Southern California, Los Angeles, California, United States
Prevention of Postpartum Depression: A Pilot Placebo-controlled Trial of Trazodone
- First Posted Date
- 2022-03-29
- Last Posted Date
- 2022-08-11
- Lead Sponsor
- Verinder Sharma
- Target Recruit Count
- 28
- Registration Number
- NCT05299398
- Locations
- 🇨🇦
Parkwood Institute Mental Health Care Building, London, Ontario, Canada
Rescue Pharmacotherapy for OSA
- Conditions
- Interventions
- First Posted Date
- 2022-03-24
- Last Posted Date
- 2024-06-04
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT05293600
- Locations
- 🇺🇸
Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts, United States
Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
- Conditions
- Interventions
- First Posted Date
- 2022-03-16
- Last Posted Date
- 2024-01-12
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 100
- Registration Number
- NCT05282550
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
Evaluation of Trazodone in OSA-MCI
- Conditions
- Interventions
- First Posted Date
- 2022-01-26
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- Chinese University of Hong Kong
- Target Recruit Count
- 134
- Registration Number
- NCT05209035
- Locations
- 🇭🇰
The Chinese University of Hong Kong, Hong Kong, Hong Kong
Investigating the Effectiveness of E-CBTi Compared to Pharmaceutical Interventions in Treating Insomnia
- First Posted Date
- 2021-11-18
- Last Posted Date
- 2024-10-18
- Lead Sponsor
- Dr. Nazanin Alavi
- Target Recruit Count
- 60
- Registration Number
- NCT05125146
- Locations
- 🇨🇦
Queen's University, Kingston, Ontario, Canada
RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ)
- Conditions
- Interventions
- First Posted Date
- 2021-10-20
- Last Posted Date
- 2024-05-08
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 30
- Registration Number
- NCT05085808
- Locations
- 🇺🇸
Keck Hospital of the University of Southern California, Los Angeles, California, United States
CBT-I or Zolpidem/Trazodone for Insomnia
- Conditions
- Interventions
- First Posted Date
- 2020-07-13
- Last Posted Date
- 2024-07-19
- Target Recruit Count
- 155
- Registration Number
- NCT04468776
- Locations
- 🇺🇸
University of Missouri, Columbia, Missouri, United States
🇺🇸Penn State Hershey Medical Center, Hershey, Pennsylvania, United States
🇺🇸University of Virginia, Charlottesville, Virginia, United States
Drug Development Updates
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