Acetazolamide
- Generic Name
- Acetazolamide
- Drug Type
- Small Molecule
- Chemical Formula
- C4H6N4O3S2
- CAS Number
- 59-66-5
- Unique Ingredient Identifier
- O3FX965V0I
- Background
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
- Indication
For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
- Associated Conditions
- Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication
- Associated Therapies
- Urine alkalinization therapy
Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
- First Posted Date
- 2025-05-20
- Last Posted Date
- 2025-05-20
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 25
- Registration Number
- NCT06981234
- Locations
- 🇺🇸
UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California, United States
Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide
- Conditions
- Idiopathic Intracranial Hypertension (IIH)
- Interventions
- Device: Stent (Tentos 4F or Precise ProRX)
- First Posted Date
- 2025-04-25
- Last Posted Date
- 2025-04-25
- Lead Sponsor
- University Hospital, Montpellier
- Target Recruit Count
- 114
- Registration Number
- NCT06945848
- Locations
- 🇫🇷
CHU de Montpellier Hôpital Gui de Chauliac, Montpellier, France
🇫🇷CHU de Reims, Reims, France
🇫🇷CHU de Toulouse, Toulouse, France
Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea
- Conditions
- Sleep Apnea
- Interventions
- First Posted Date
- 2025-01-15
- Last Posted Date
- 2025-04-29
- Lead Sponsor
- Shionogi Apnimed Sleep Science
- Target Recruit Count
- 60
- Registration Number
- NCT06776432
- Locations
- 🇺🇸
Teradan Clinical Trials, Brandon, Florida, United States
🇺🇸PharmaDev Clinical Research Institute, LLC, Miami, Florida, United States
🇺🇸Intrepid Research, LLC, Cincinnati, Ohio, United States
Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients
- Conditions
- Acute Decompensated Heart Failure
- Interventions
- First Posted Date
- 2024-08-02
- Last Posted Date
- 2024-08-05
- Lead Sponsor
- Helwan University
- Target Recruit Count
- 60
- Registration Number
- NCT06535529
- Locations
- 🇪🇬
Critical Care Medicine Department - Cairo University Hospitals., Cairo, Egypt
Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder
- Conditions
- Central Sleep Apnea Comorbid With Opioid Use
- Interventions
- Drug: Placebo
- First Posted Date
- 2024-07-26
- Last Posted Date
- 2025-04-03
- Lead Sponsor
- Sanjay R Patel
- Target Recruit Count
- 40
- Registration Number
- NCT06521476
- Locations
- 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States
HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 270
- Registration Number
- NCT06498505
- Locations
- 🇰🇬
National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 270
- Registration Number
- NCT06498531
- Locations
- 🇰🇬
National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 270
- Registration Number
- NCT06499727
- Locations
- 🇰🇬
National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes
- Conditions
- Acute Decompensated Heart Failure
- Interventions
- Drug: Placebo
- First Posted Date
- 2024-06-26
- Last Posted Date
- 2024-10-22
- Lead Sponsor
- Universitas Diponegoro
- Target Recruit Count
- 66
- Registration Number
- NCT06475105
- Locations
- 🇮🇩
Department of Cardiology and Vascular Medicine, Universitas Diponegoro, Kariadi Central General Hospital, Semarang, Central Java, Indonesia
🇮🇩Kariadi Central General Hospital, Semarang, Central Java, Indonesia
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
- Conditions
- Acute Decompensated Heart FailureVolume OverloadEdema
- Interventions
- First Posted Date
- 2024-05-16
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 110
- Registration Number
- NCT06414759
- Locations
- 🇪🇬
National Heart Institute, Giza, GZ, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.