Acetazolamide

Generic Name
Acetazolamide
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C4H6N4O3S2
CAS Number
59-66-5
Unique Ingredient Identifier
O3FX965V0I
Background

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of...

Indication

For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions
Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication
Associated Therapies
Urine alkalinization therapy
Clinical Trials
Related News

Acetazolamide in Decompensated Heart Failure With Volume OveRload (ADVOR)

First Posted Date
2018-04-23
Last Posted Date
2024-10-28
Lead Sponsor
Ziekenhuis Oost-Limburg
Target Recruit Count
519
Registration Number
NCT03505788
Locations
🇧🇪

Ziekenhuis Oost-Limburg AV, Genk, Limburg, Belgium

Surgical Idiopathic Intracranial Hypertension Treatment Trial

First Posted Date
2018-04-18
Last Posted Date
2022-06-16
Lead Sponsor
Jaeb Center for Health Research
Target Recruit Count
7
Registration Number
NCT03501966
Locations
🇺🇸

New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States

🇺🇸

Stanford University, Palo Alto, California, United States

🇺🇸

State University of New York at Stony Brook, East Setauket, New York, United States

and more 33 locations

Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography

First Posted Date
2018-04-06
Last Posted Date
2019-05-10
Lead Sponsor
Vincent Kan
Target Recruit Count
18
Registration Number
NCT03490916
Locations
🇺🇸

UMass Medical School, Worcester, Massachusetts, United States

Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages

Phase 1
Completed
Conditions
Acute Mountain Sickness
Interventions
Drug: Acetazolamide
First Posted Date
2018-02-06
Last Posted Date
2018-11-20
Lead Sponsor
Stanford University
Target Recruit Count
105
Registration Number
NCT03424226
Locations
🇺🇸

Stanford University, Stanford, California, United States

Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm

First Posted Date
2017-12-19
Last Posted Date
2023-07-27
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
11
Registration Number
NCT03377049
Locations
🇺🇸

University of Wisconsin, Madison, Wisconsin, United States

Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy

Phase 1
Completed
Conditions
Acute Mountain Sickness
Interventions
Drug: Ibuprofen
Drug: Acetazolamide
First Posted Date
2017-05-16
Last Posted Date
2018-11-26
Lead Sponsor
Grant S Lipman
Target Recruit Count
92
Registration Number
NCT03154645
Locations
🇺🇸

White Mountain Research Station, Bishop, California, United States

Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position.

Not Applicable
Completed
Conditions
IOP
Interventions
Drug: Placebo
Drug: Acetazolamide
Other: Trendelenburg Position
First Posted Date
2017-04-11
Last Posted Date
2017-04-11
Lead Sponsor
University of Nottingham
Target Recruit Count
9
Registration Number
NCT03107429

Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma

First Posted Date
2017-01-05
Last Posted Date
2024-05-13
Lead Sponsor
University of Chicago
Target Recruit Count
60
Registration Number
NCT03011671
Locations
🇺🇸

University of Chicago Medical Center, Chicago, Illinois, United States

Effect of Acetazolamide on Optic Nerve Sheath Diameter in Laparoscopic Donor Nephrectomies

Not Applicable
Completed
Conditions
Intracranial Pressure Increase
Interventions
Drug: Normal Saline
Drug: Acetazolamide
First Posted Date
2016-12-29
Last Posted Date
2016-12-29
Lead Sponsor
Post Graduate Institute of Medical Education and Research, Chandigarh
Target Recruit Count
40
Registration Number
NCT03005665
Locations
🇮🇳

PGIMER, Chandigarh, India

Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia

First Posted Date
2016-12-14
Last Posted Date
2018-12-31
Lead Sponsor
University of Chile
Target Recruit Count
50
Registration Number
NCT02992938
Locations
🇨🇱

Faculty of Medicine, University of Chile, Santiago, Metropolitana, Chile

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