Trazodone

Generic Name
Trazodone
Brand Names
Desyrel, Oleptro
Drug Type
Small Molecule
Chemical Formula
C19H22ClN5O
CAS Number
19794-93-5
Unique Ingredient Identifier
YBK48BXK30
Background

Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibito...

Indication

Trazodone is indicated for the treatment of major depressive disorder (MDD). It has been used off-label for adjunct therapy in alcohol dependence, and off-label to treat anxiety and insomnia. It may also be used off-label to treat symptoms of dementia, Alzheimer’s disease, schizophrenia, eating disorders, and fibromyalgia due to its effects on various neurot...

Associated Conditions
Alcohol Dependency, Alzheimer's Disease (AD), Anxiety, Dementia, Eating Disorders Symptoms, Fibromyalgia, Insomnia, Major Depressive Disorder (MDD), Pain, Inflammatory, Schizophrenia, Moderate to severe pain
Associated Therapies
-

Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI

First Posted Date
2015-06-01
Last Posted Date
2021-06-14
Lead Sponsor
VA Office of Research and Development
Target Recruit Count
15
Registration Number
NCT02458469
Locations
🇺🇸

John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium

First Posted Date
2014-04-21
Last Posted Date
2019-09-10
Lead Sponsor
Rochester General Hospital
Registration Number
NCT02118688
Locations
🇺🇸

Rochester General Hospital, Rochester, New York, United States

Trazodone Once a Day in Major Depression Disorder

Phase 3
Completed
Conditions
Interventions
First Posted Date
2014-03-13
Last Posted Date
2015-12-30
Lead Sponsor
Aziende Chimiche Riunite Angelini Francesco S.p.A
Target Recruit Count
364
Registration Number
NCT02086929
Locations
🇨🇿

PRAGTIS, s.r.o., Praha 2, Praha, Czech Republic

🇨🇿

Psychiatry Trial, s.r.o., Praha 5, Praha, Czech Republic

🇷🇴

Quantum Medical Center Srl, Bucharest, Romania

and more 29 locations

The Effects of Trazodone on Sleep Apnea Severity

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-03-26
Last Posted Date
2017-02-24
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
15
Registration Number
NCT01817907
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

First Posted Date
2012-08-10
Last Posted Date
2018-10-16
Lead Sponsor
VA Connecticut Healthcare System
Target Recruit Count
1
Registration Number
NCT01662297
Locations
🇺🇸

VA Connecticut Healthcare System, West Haven, Connecticut, United States

Sequenced Therapies for Comorbid and Primary Insomnias

First Posted Date
2012-07-27
Last Posted Date
2021-03-29
Lead Sponsor
Jack Edinger, PhD
Target Recruit Count
211
Registration Number
NCT01651442
Locations
🇨🇦

Université Laval, Quebec City, Quebec, Canada

🇺🇸

National Jewish Health, Denver, Colorado, United States

A Clinical Study of Trazodone Hydrochloride Prolonged-Release Tablets for Treatment of Depression

Phase 2
Completed
Conditions
Interventions
First Posted Date
2012-02-02
Last Posted Date
2014-10-16
Lead Sponsor
Lee's Pharmaceutical Limited
Target Recruit Count
382
Registration Number
NCT01524497
Locations
🇨🇳

The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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