Hydrocodone
- Generic Name
- Hydrocodone
- Brand Names
- Dalmacol, Hycet, Hycodan, Hydromet, Hysingla, Lorcet, Lortab, Norco, Obredon, Reprexain, Tussicaps, Tussionex, Vicoprofen, Xodol, Zamicet, Zohydro, Zydone
- Drug Type
- Small Molecule
- Chemical Formula
- C18H21NO3
- CAS Number
- 125-29-1
- Unique Ingredient Identifier
- 6YKS4Y3WQ7
- Background
Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.
- Indication
Hydrocodone is indicated for the management of acute pain, sometimes in combination with acetaminophen or ibuprofen, as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.
- Associated Conditions
- Acute Pain, Chronic Pain, Cough, Cough caused by Allergic Rhinitis, Cough caused by Common Cold, Nasal Congestion caused by Allergic Rhinitis, Nasal Congestion caused by Common Cold, Rhinitis caused by Common Cold, Severe Pain, Moderate Pain, Upper respiratory symptoms caused by Allergic Rhinitis, Upper respiratory symptoms caused by Common Cold
Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2024-09-05
- Last Posted Date
- 2024-09-05
- Lead Sponsor
- Quivive Pharma, Inc.
- Target Recruit Count
- 8
- Registration Number
- NCT06585163
- Locations
- 🇺🇸
Cleveland Clinic Main Campus, Cleveland, Ohio, United States
Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction
- Conditions
- Pain, AcutePain, Post-operativeThird MolarOral Surgery
- Interventions
- First Posted Date
- 2024-07-03
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- United States Naval Medical Center, San Diego
- Target Recruit Count
- 80
- Registration Number
- NCT06484439
- Locations
- 🇺🇸
Naval Medical Center San Diego, San Diego, California, United States
5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial
- Conditions
- Intra-abdominal Cancer
- Interventions
- First Posted Date
- 2024-01-31
- Last Posted Date
- 2025-04-11
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 170
- Registration Number
- NCT06232577
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia
- Conditions
- Nail DiseasesNail Abnormality
- Interventions
- First Posted Date
- 2022-09-16
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 20
- Registration Number
- NCT05544734
- Locations
- 🇺🇸
Weill Medical College of Cornell University, New York, New York, United States
Multimodal Analgesia Effect on Post Surgical Patient
- Conditions
- Obesity, MorbidSurgeryBariatric Surgery Candidate
- Interventions
- First Posted Date
- 2020-01-27
- Last Posted Date
- 2025-03-21
- Lead Sponsor
- University of California, Davis
- Target Recruit Count
- 60
- Registration Number
- NCT04240626
- Locations
- 🇺🇸
UC Davis Health, Sacramento, California, United States
Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain
- First Posted Date
- 2019-07-05
- Last Posted Date
- 2019-11-13
- Lead Sponsor
- Boston University
- Registration Number
- NCT04008043
- Locations
- 🇺🇸
Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, United States
Battlefield Acupuncture for Acute/Subacute Back Pain in the Emergency Department
- Conditions
- Low Back Pain, Mechanical
- Interventions
- Device: Battlefield Acupuncture
- First Posted Date
- 2019-06-25
- Last Posted Date
- 2019-06-26
- Lead Sponsor
- San Antonio Military Medical Center
- Target Recruit Count
- 26
- Registration Number
- NCT03996564
Study to Evaluate Drug-drug Interactions of Guaifenesin and Hydrocodone Bitartrate
- Conditions
- Healthy Subjects
- Interventions
- First Posted Date
- 2018-08-22
- Last Posted Date
- 2019-06-20
- Lead Sponsor
- Reckitt Benckiser LLC
- Target Recruit Count
- 24
- Registration Number
- NCT03642873
Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer
- Conditions
- Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm
- Interventions
- Other: Questionnaire Administration
- First Posted Date
- 2018-07-06
- Last Posted Date
- 2025-03-25
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 43
- Registration Number
- NCT03579446
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
To Evaluate the Relative Abuse Potential of Hydrocodone Bitartrate and Acetaminophen
- Conditions
- Healthy
- Interventions
- Drug: PlaceboDrug: Reference
- First Posted Date
- 2018-06-26
- Last Posted Date
- 2019-04-29
- Lead Sponsor
- Sun Pharma Advanced Research Company Limited
- Target Recruit Count
- 32
- Registration Number
- NCT03567941
- Locations
- 🇨🇦
SPARC Site 1, Toronto, Ontario, Canada
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.