Hydromorphone
- Generic Name
- Hydromorphone
- Brand Names
- Dilaudid, Exalgo, Hydromorph Contin, Hydromorphone Hp Forte
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 466-99-9
- Unique Ingredient Identifier
- Q812464R06
- Background
Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it present...
- Indication
Hydromorphone is indicated for the management of moderate to severe acute pain and severe chronic pain. Due to its addictive potential and overdose risk, hydromorphone is only prescribed when other first-line treatments have failed.
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- Associated Conditions
- Neuropathic Pain, Refractory Chronic Cough, Moderate to severe pain
- Associated Therapies
- -
Personalized Post-Operative Pain Management
- Conditions
- Interventions
- First Posted Date
- 2024-11-01
- Last Posted Date
- 2024-11-01
- Target Recruit Count
- 208
- Registration Number
- NCT06669650
- Locations
- 🇺🇸
The University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, United States
Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-07-29
- Last Posted Date
- 2024-07-29
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 140
- Registration Number
- NCT06525740
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
- Conditions
- Interventions
- First Posted Date
- 2024-05-13
- Last Posted Date
- 2024-05-13
- Lead Sponsor
- Masonic Cancer Center, University of Minnesota
- Target Recruit Count
- 78
- Registration Number
- NCT06411795
- Locations
- 🇺🇸
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, United States
Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).
- Conditions
- Interventions
- First Posted Date
- 2024-05-09
- Last Posted Date
- 2024-11-21
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 15
- Registration Number
- NCT06406400
- Locations
- 🇺🇸
Research Site, Baltimore, Maryland, United States
Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia
- Conditions
- Interventions
- First Posted Date
- 2023-09-14
- Last Posted Date
- 2023-10-26
- Target Recruit Count
- 240
- Registration Number
- NCT06036797
- Locations
- 🇨🇳
Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China
Effect of Epidural Hydromorphone Combined With Ropivacaine in Labor Analgesia
- Conditions
- Interventions
- First Posted Date
- 2023-06-13
- Last Posted Date
- 2023-06-13
- Target Recruit Count
- 240
- Registration Number
- NCT05901441
- Locations
- 🇨🇳
Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, China
NSAID Use After Robotic Partial Nephrectomy
- Conditions
- Interventions
- First Posted Date
- 2023-05-03
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 110
- Registration Number
- NCT05842044
- Locations
- 🇺🇸
University of Miami, Miami, Florida, United States
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, N-Acetylcysteine)
- Conditions
- Interventions
- First Posted Date
- 2022-11-09
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- William Stoops
- Target Recruit Count
- 24
- Registration Number
- NCT05610072
- Locations
- 🇺🇸
University of Kentucky Laboratory of Human Behavioral Pharmacology, Lexington, Kentucky, United States
🇺🇸University of Kentucky Department of Behavioral Science, Lexington, Kentucky, United States
The Effects of ECMO on the Pharmacokinetics of Hydromorphone
- First Posted Date
- 2022-10-04
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- Xiaobo Yang, MD
- Target Recruit Count
- 26
- Registration Number
- NCT05565495
- Locations
- 🇨🇳
Wuhan Union Hospital, Wuhan, Hubei, China
Comparison of Short-term Sustained-release Opioid in Open Abdominal Urologic Surgeries
- First Posted Date
- 2022-05-17
- Last Posted Date
- 2024-05-17
- Lead Sponsor
- University of Alberta
- Target Recruit Count
- 80
- Registration Number
- NCT05375916
- Locations
- 🇨🇦
University of Alberta Hospital, Edmonton, Alberta, Canada
Drug Development Updates
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