Methadone
- Generic Name
- Methadone
- Brand Names
- Diskets, Dolophine, Metadol, Metadol-D, Methadose
- Drug Type
- Small Molecule
- Chemical Formula
- C21H27NO
- CAS Number
- 76-99-3
- Unique Ingredient Identifier
- UC6VBE7V1Z
- Background
Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a number of uniqu...
- Indication
Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It's recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwis...
- Associated Conditions
- Opioid Addiction, Severe Pain
- Associated Therapies
- Opioid Detoxification, Maintenance therapy
Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery
- First Posted Date
- 2024-12-11
- Last Posted Date
- 2024-12-11
- Lead Sponsor
- Chinese University of Hong Kong
- Target Recruit Count
- 86
- Registration Number
- NCT06728371
- Locations
- 🇭🇰
Prince of Wales Hospital, Hong Kong, Hong Kong
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
- Conditions
- Interventions
- First Posted Date
- 2024-08-29
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- Duke University
- Target Recruit Count
- 440
- Registration Number
- NCT06576830
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.
- First Posted Date
- 2024-08-05
- Last Posted Date
- 2024-12-03
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 100
- Registration Number
- NCT06536517
Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-07-29
- Last Posted Date
- 2024-07-29
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 140
- Registration Number
- NCT06525740
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intrathecal Morphine in Major Abdominal Surgery
- First Posted Date
- 2024-04-29
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 40
- Registration Number
- NCT06387303
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
- First Posted Date
- 2024-03-21
- Last Posted Date
- 2024-08-29
- Lead Sponsor
- Yale University
- Target Recruit Count
- 600
- Registration Number
- NCT06323824
- Locations
- 🇺🇸
Highland Hospital Bridge Clinic at Alameda Health System, Oakland, California, United States
🇺🇸Marshall University Division of Addiction Sciences P.R.O.A.C.T, Huntington, West Virginia, United States
🇺🇸Officed Based Addiction Treatment Program, Boston Medical Center, Boston, Massachusetts, United States
Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients
- Conditions
- Interventions
- First Posted Date
- 2023-06-22
- Last Posted Date
- 2024-02-07
- Lead Sponsor
- Chinese University of Hong Kong
- Target Recruit Count
- 86
- Registration Number
- NCT05913284
- Locations
- 🇭🇰
Prince of Wales Hospital, Hong Kong, Hong Kong
Symptom-inhibited Fentanyl Induction
- Conditions
- Interventions
- First Posted Date
- 2023-06-15
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- Pouya Azar
- Target Recruit Count
- 50
- Registration Number
- NCT05905367
- Locations
- 🇨🇦
Hope to Health Research & Innovation Centre, Vancouver, British Columbia, Canada
Intraoperative Methadone for Postoperative Pain Control
- First Posted Date
- 2023-05-06
- Last Posted Date
- 2023-10-18
- Lead Sponsor
- Montefiore Medical Center
- Registration Number
- NCT05845359
Methadone to Treat Painful Chemotherapy Induced Peripheral Neuropathy
- Conditions
- Interventions
- First Posted Date
- 2023-03-27
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 50
- Registration Number
- NCT05786599
Drug Development Updates
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