DeepMed Research

Hydrocodone

Generic Name: Hydrocodone

Brand Names: Dalmacol, Hycet, Hycodan, Hydromet, Hysingla, Lorcet, Lortab, Norco, Obredon, Reprexain, Tussicaps, Tussionex, Vicoprofen, Xodol, Zamicet, Zohydro, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₁NO_₃

CAS Number: 125-29-1

Unique Ingredient Identifier: 6YKS4Y3WQ7

Background: Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.

Indication: Hydrocodone is indicated for the management of acute pain, sometimes in combination with acetaminophen or ibuprofen, as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.

Associated Conditions: Acute Pain, Chronic Pain, Cough, Cough caused by Allergic Rhinitis, Cough caused by Common Cold, Nasal Congestion caused by Allergic Rhinitis, Nasal Congestion caused by Common Cold, Rhinitis caused by Common Cold, Severe Pain, Moderate Pain, Upper respiratory symptoms caused by Allergic Rhinitis, Upper respiratory symptoms caused by Common Cold

Clinical Trials

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting

Conditions: Breastfed Infants of Mothers on Select DOI
Lactating Women on Select DOI

First Posted Date: 2018-04-27

Last Posted Date: 2024-12-17

Lead Sponsor: Duke University

Target Recruit Count: 1600

Registration Number: NCT03511118

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸
Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸
Loma Linda University Health, Loma Linda, California, United States

and more 19 locations

Narcotic Versus Non-narcotic Medication for Pain Management After Wrist/Hand Fractures

Phase 4

Conditions: Metacarpal Fracture
Pain Management
Distal Radius Fracture

Interventions: Drug: Acetaminophen 500Mg Tab
Drug: Hydrocodone 5Mg/Acetaminophen 500Mg Tab
Drug: Ibuprofen 600 mg tab

First Posted Date: 2017-12-18

Last Posted Date: 2021-03-01

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 250

Registration Number: NCT03375593

Locations: 🇨🇦
St. Joseph Health Care, London, Ontario, Canada

Bandage Contact Lenses for Corneal Abrasions

Phase 2

Conditions: Corneal Abrasion
Eye Trauma

Interventions: Drug: Eyedrop
Device: Bandage contact lens
Drug: Hydrocodone

First Posted Date: 2017-07-02

Last Posted Date: 2018-02-01

Lead Sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Target Recruit Count: 60

Registration Number: NCT03206723

Locations: 🇺🇸
Harbor-UCLA Medical Center, Torrance, California, United States

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron

First Posted Date: 2015-12-09

Last Posted Date: 2019-03-07

Lead Sponsor: Vanderbilt University

Target Recruit Count: 27034

Registration Number: NCT02625181

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Bioavailability Study of SPARC001 in Healthy Adult Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: SPARC001B
Drug: Reference001 - Hydrocodone
Drug: SPARC001A

First Posted Date: 2015-12-01

Last Posted Date: 2019-05-03

Lead Sponsor: Sun Pharma Advanced Research Company Limited

Target Recruit Count: 18

Registration Number: NCT02618395

Acupuncture for Pain in the Emergency Department

Early Phase 1

Withdrawn

Conditions: Musculoskeletal Pain
Pain

Interventions: Device: Acupuncture
Procedure: Auricular Acupuncture
Procedure: Placebo Acupuncture
Drug: hydrocodone / acetaminophen 5mg/325mg
Drug: Placebo Pill

First Posted Date: 2015-09-04

Last Posted Date: 2017-07-28

Lead Sponsor: Loma Linda University

Registration Number: NCT02540512

A Four-Period, Four-Treatment, Four-Way Relative Bioavailability Study of CL-108 Under Fed and Fasted Conditions

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Vicoprofen
Drug: CL-108
Drug: Ultracet
Drug: Phenergan

First Posted Date: 2015-06-09

Last Posted Date: 2017-05-02

Lead Sponsor: Charleston Laboratories, Inc

Target Recruit Count: 20

Registration Number: NCT02465866

Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals

Not Applicable

Conditions: Analgesic Response

Interventions: Drug: oral tablet placebo
Drug: sublingual tablet placebo
Drug: morphine sulfate
Drug: buprenorphine
Drug: hydrocodone
Drug: hydromorphone HCI
Drug: oxycodone

First Posted Date: 2014-05-13

Last Posted Date: 2014-05-13

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 12

Registration Number: NCT02136784

Locations: 🇺🇸
UCLA Integrated Substance Abuse Programs Outpatient Clinical Research Center, Los Angeles, California, United States

Decreasing Narcotics in Advanced Pelvic Surgery

Phase 4

Completed

Conditions: Constipation
Narcotic Use
Pain
Nausea

Interventions: Drug: oral acetaminophen
Drug: Celebrex
Drug: oral ibuprofen
Drug: Gabapentin
Drug: percocet
Drug: IV acetaminophen
Drug: vicodin
Drug: Oxycodone
Drug: dilaudid
Drug: Dexamethasone
Drug: zofran

First Posted Date: 2014-04-10

Last Posted Date: 2016-08-17

Lead Sponsor: Hartford Hospital

Target Recruit Count: 138

Registration Number: NCT02110719

Locations: 🇺🇸
Hartford Hosptial, Hartford, Connecticut, United States

Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets

Phase 3

Completed

Conditions: Low Back Pain

Interventions: Drug: Hydrocodone ER
Drug: Placebo

First Posted Date: 2013-08-14

Last Posted Date: 2021-11-09

Lead Sponsor: Teva Branded Pharmaceutical Products R&D, Inc.

Target Recruit Count: 182

Registration Number: NCT01922739

Locations: 🇺🇸
Teva Investigational Site 10426, Mobile, Alabama, United States
🇺🇸
Teva Investigational Site 10425, Carmichael, California, United States
🇺🇸
Teva Investigational Site 10370, Los Angeles, California, United States

and more 58 locations

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2025. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy