Clonazepam
- Generic Name
- Clonazepam
- Brand Names
- Clonapam, Klonopin, Rivotril
- Drug Type
- Small Molecule
- Chemical Formula
- C15H10ClN3O3
- CAS Number
- 1622-61-3
- Unique Ingredient Identifier
- 5PE9FDE8GB
- Background
A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. The agent has also been indicated for treating panic disorder. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.
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- Indication
Clonazepam is indicated as monotherapy or as an adjunct in the treatment of Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. Furthermore, clonazepam may also be of some value in patients with absence spells (petit mal) who have failed to respond to succinimides. Additionally, clonazepam is also indicated for the treatment of pan...
- Associated Conditions
- Akinetic seizures, Burning Mouth Syndrome, Essential Tremor, Gilles de la Tourette's Syndrome, Lennox-Gastaut Syndrome, Mixed manic depressive episode, Panic Disorder, Rapid Eye Movement Sleep Disorder, Restless Legs Syndrome (RLS), Tardive Dyskinesia (TD), Acute Manic episode, Myoclonic seizures, Refractory absence Seizures
- Associated Therapies
- -
Enhancing Mobility and Mental Health in Dementia Patients
- First Posted Date
- 2024-09-24
- Last Posted Date
- 2024-09-24
- Lead Sponsor
- Oxleas NHS Foundation Trust
- Target Recruit Count
- 6
- Registration Number
- NCT06611202
- Locations
- 🇬🇧
Holbrook ward, Sidcup, United Kingdom
Detoxification From the Lipid Tract
- Conditions
- Interventions
- Device: electroencephalogram biofeedbackDevice: electrical brain stimulationDevice: ultra-low frequency transcranial magnetic stimulationDrug: Sertraline HydrochlorideDrug: ClonazepamDrug: AlprazolamDrug: MetoprololDrug: OlanzapineDrug: Pravastatin Sodium 20 MGDrug: Sacubitril Valsartan Sodium Hydrate
- First Posted Date
- 2024-04-10
- Last Posted Date
- 2024-04-10
- Lead Sponsor
- Pachankis, Yang I., M.D.
- Target Recruit Count
- 1
- Registration Number
- NCT06357104
- Locations
- 🇨🇳
Residential Address, Chongqing, Chongqing, China
Inflammatory Markers in Saliva of Patients With Burning Mouth Syndrome
- Conditions
- Interventions
- First Posted Date
- 2024-01-22
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Universidad de Murcia
- Target Recruit Count
- 20
- Registration Number
- NCT06217731
- Locations
- 🇪🇸
Pia Lopez Jornet, Murcia, Spain
Psychopharmacological Treatment of Emotional Distress
- Conditions
- Interventions
- First Posted Date
- 2023-11-15
- Last Posted Date
- 2024-06-07
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 80
- Registration Number
- NCT06133114
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2017-02-23
- Last Posted Date
- 2018-04-05
- Lead Sponsor
- Palo Alto Veterans Institute for Research
- Registration Number
- NCT03061136
- Locations
- 🇺🇸
VA Palo Alto Health Care System, Palo Alto, California, United States
Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients
- First Posted Date
- 2016-09-26
- Last Posted Date
- 2021-08-06
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 68
- Registration Number
- NCT02913924
- Locations
- 🇺🇸
Substance Treatment Research Service (STARS) of Columbia University, New York, New York, United States
Long Term Treatment of Panic Disorder With Clonazepam or Paroxetine
- First Posted Date
- 2016-08-02
- Last Posted Date
- 2016-08-02
- Lead Sponsor
- Universidade Federal do Rio de Janeiro
- Target Recruit Count
- 120
- Registration Number
- NCT02852577
- Locations
- 🇧🇷
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease
- First Posted Date
- 2016-06-03
- Last Posted Date
- 2016-06-03
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT02789592
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome
- Conditions
- Interventions
- First Posted Date
- 2016-02-24
- Last Posted Date
- 2018-05-03
- Lead Sponsor
- University of Alberta
- Registration Number
- NCT02690844
Acupuncture Versus Clonazepam in Burning Mouth Syndrome
- Conditions
- Interventions
- First Posted Date
- 2015-03-06
- Last Posted Date
- 2015-03-06
- Lead Sponsor
- University of Zagreb
- Target Recruit Count
- 4
- Registration Number
- NCT02382029
Drug Development Updates
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